Abstract D104: Presentation, treatment, and survival of hepatocellular carcinoma (HCC) in a diverse population: Experience of a single transplant center

Background: HCC has pathognomonic imaging and predominantly non-surgical treatment paradigms. Most patients do not have histological diagnosis, an integral part of case identification for population based cancer registries. The unique patterns of diagnosis and treatment may hamper population-based s...

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Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-06, Vol.29 (6_Supplement_2), p.D104-D104
Main Authors: Barzi, Afsaneh, Patel, Ravi, Tulpule, Varsha, Albertian, Robert, Yu, Bo, Lynch, Gwendolyn, El-Khoueiry, Anthony, Wang, Songren, Setiawan, Veronica Wendy
Format: Article
Language:English
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Summary:Background: HCC has pathognomonic imaging and predominantly non-surgical treatment paradigms. Most patients do not have histological diagnosis, an integral part of case identification for population based cancer registries. The unique patterns of diagnosis and treatment may hamper population-based study of HCC outcomes and patterns of care. We examined racial differences in the HCC underlying etiology, presentation, treatment, and outcome in a diverse patient population in a single transplant center. Methods: HCC patients who were diagnosed/treated at Norris Comprehensive Cancer Center between 2003-2018 were identified from cancer registry. Registry data including vital status were linked with medical records. Demographics, stage at diagnosis [Barcelona Clinic Liver Cancer stage (BCLC) and Tumor Node Metastasis (TNM)], underlying etiology [hepatitis C (HCV), hepatitis B (HBV), nonalcoholic steatohepatitis (NASH), alcoholic liver disease], treatment information, and vital status were retrieved. The chi-square test was used to compare characteristics of patients by race. Multivariable Cox’s models were used to identify factors associated with overall survival. Results: A total of 619 patients (152 non-Hispanic whites (NHW), 285 Hispanics, 158 Asians, and 24 African Americans) were included in the analysis. The median follow-up was 27.0 months. The average age at diagnosis was 63 years, and 76% of patients were male. Underlying etiology varied significantly across racial groups (P
ISSN:1055-9965
1538-7755
DOI:10.1158/1538-7755.DISP19-D104