Growth, Food Intake, Motor Activity and Experimental Cardiac Necrosis in Early Malnourished Male Rats

Male rats with protein energy malnutrition from birth to the 49th day of life (PEM) and then receiving normal diet ad libitum had lower body weights and relatively higher food intakes (g/100 g body weight) than controls (C). Spontaneous motor activity measured in rotation wheels from the 42nd day wa...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 1982-01, Vol.26 (2), p.121-128
Main Authors: Pařízková, Jana, Faltová, Eva, Mráz, M., Špátová, Milada
Format: Article
Language:English
Subjects:
Aging
Animals
Cardiomyopathies - chemically induced
Cardiomyopathies - pathology
Diet
Growth
Isoproterenol
Male
Motor Activity - physiology
Myocardium - pathology
Necrosis
Organ Size
Protein-Energy Malnutrition - pathology
Protein-Energy Malnutrition - physiopathology
Rats
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Summary:Male rats with protein energy malnutrition from birth to the 49th day of life (PEM) and then receiving normal diet ad libitum had lower body weights and relatively higher food intakes (g/100 g body weight) than controls (C). Spontaneous motor activity measured in rotation wheels from the 42nd day was higher in previously malnourished animals, but less food was consumed per gram of weight increment during this period by rats as compared to C rats. The cardiotoxicity of isoprenaline administered at the age of 110 days was significantly lower, i.e. the cardiac damage was smaller in previously malnourished animals (PEM). This was most apparent when they were compared with inactive controls living in standard laboratory cages.
ISSN:0250-6807
1421-9697
DOI:10.1159/000176554