High Prevalence of Orthostatic Hypotension in Mild Dementia

Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild dementia were diagnosed according to consensus criteria after comprehensive s...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 2009-01, Vol.28 (4), p.307-313
Main Authors: Sonnesyn, Hogne, Nilsen, Dennis W., Rongve, Arvid, Nore, Sabine, Ballard, Clive, Tysnes, Ole B., Aarsland, Dag
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood Pressure - physiology
Cohort Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - complications
Dementia - epidemiology
Electrocardiography
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Hypotension, Orthostatic - complications
Hypotension, Orthostatic - epidemiology
Lewy Body Disease - complications
Lewy Body Disease - epidemiology
Lewy Body Disease - physiopathology
Long QT Syndrome - epidemiology
Long QT Syndrome - physiopathology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Original Research Article
Prospective Studies
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Summary:Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild dementia were diagnosed according to consensus criteria after comprehensive standardized assessment. OH and QTc were assessed using standardized criteria. Results: OH was significantly more common in the dementia than in the control group, and systolic drop was higher in those with dementia with Lewy bodies. There were no significant differences in QTc values between dementia and control subjects. Conclusion: OH occurs even in patients with mild dementia, in particular in dementia with Lewy bodies. QTc was not prolonged in patients with mild dementia compared with normal controls.
ISSN:1420-8008
1421-9824
DOI:10.1159/000247586