The Immunomodulatory Effect of the Antidepressant Sertraline in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis

Background: We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors. Objectives: In this research, we performed an in vivo/ex vivo study to evaluate the potential immunosuppressive effect of sertraline in an experimental autoimmune encephalomyeli...

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Bibliographic Details
Published in:Neuroimmunomodulation 2011-01, Vol.18 (2), p.117-122
Main Authors: Taler, Michal, Gil-Ad, Irit, Korob, Inna, Weizman, Abraham
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - pharmacology
Cell Survival - drug effects
Cytokines - biosynthesis
Cytokines - drug effects
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Encephalomyelitis, Autoimmune, Experimental - immunology
Female
Immunologic Factors - pharmacology
Lymphocytes - drug effects
Lymphocytes - immunology
Mice
Mice, Inbred C57BL
Multiple Sclerosis - immunology
Original Paper
Serotonin Uptake Inhibitors - pharmacology
Sertraline - pharmacology
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Summary:Background: We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors. Objectives: In this research, we performed an in vivo/ex vivo study to evaluate the potential immunosuppressive effect of sertraline in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Methods: Mice (C57/bl EAE) were treated with sertraline (5 mg/kg) or dexamethasone (1 mg/kg) 7 days after EAE induction and then 3 times weekly (for 3 weeks). Results: Sertraline modestly improved the clinical score of EAE and attenuated the disease-induced weight loss. Sertraline also significantly decreased ex-vivo splenocyte viability, proliferation and secretion of pro-inflammatory cytokines in EAE mice. Conclusions: We suggest that sertraline might be an add-on option for multiple sclerosis treatment.
ISSN:1021-7401
1423-0216
DOI:10.1159/000321634