Failure of ticlopidine to inhibit deposition of indium-111-labeled platelets on Dacron prosthetic surfaces in humans

In a randomized double-blind trial we sought to determine whether short-term therapy with ticlopidine (250 mg bid for 14 days) inhibited platelet deposition on Dacron aortic bifurcation grafts that had been in place a year or longer. A total of 10 men, 42 to 69 years old, underwent indium-111 platel...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1984-04, Vol.69 (4), p.677-683
Main Authors: STRATTON, J. R, RITCHIE, J. L
Format: Article
Language:English
Subjects:
Adult
Aged
Aorta
Biological and medical sciences
Bleeding Time
Blood Platelets - diagnostic imaging
Blood Vessel Prosthesis
Blood. Blood coagulation. Reticuloendothelial system
Clinical Trials as Topic
Humans
Indium
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Placebos
Platelet Adhesiveness - drug effects
Polyethylene Terephthalates
Radioisotopes
Radionuclide Imaging
Thiophenes - adverse effects
Thiophenes - pharmacology
Ticlopidine
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Summary:In a randomized double-blind trial we sought to determine whether short-term therapy with ticlopidine (250 mg bid for 14 days) inhibited platelet deposition on Dacron aortic bifurcation grafts that had been in place a year or longer. A total of 10 men, 42 to 69 years old, underwent indium-111 platelet imaging during both placebo and drug phases of the trial at 24, 48, and 72 hr after the injection of labeled platelets. Platelet accumulation was quantitated by a graft/blood ratio that compared background-corrected activity of indium-111-labeled platelets in the graft with whole-blood activity of indium-111-labeled platelets. Additionally, blinded qualitative visual analysis of the unprocessed images was used to compare graft area activity with activity in adjacent native arteries. Ticlopidine significantly prolonged the template bleeding time from 5.3 +/- 0.5 to 17.1 +/- 3.1 min (+/- SEM) (p = .003). However, by quantitative analysis there was no significant reduction in platelet deposition in the graft during ticlopidine therapy compared with placebo at 24 hr (graft/blood ratio 2.3 +/- 0.4 vs 2.6 +/- 0.3), 48 hr (3.1 +/- 0.5 vs 3.2 +/- 0.4), or 72 hr (3.9 +/- 0.7 vs 4.0 +/- 0.6) after injection of labeled platelets. By visual analysis, nine patients had positive results for abnormal platelet deposition when on placebo that were unchanged when on ticlopidine. The tenth patient had an equivocal result for abnormal platelet deposition when on placebo and a negative result for abnormal platelet deposition when on ticlopidine.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.69.4.677