Role of ischemia in contrast-induced renal damage: an experimental study

Total and regional cortical blood flow was measured in dogs by the radioactive microsphere technique after renal damage of varying severity had been induced by combining selective injection of diatrizoate, iopamidol, or normal saline with a 10 min occlusion of the renal artery. There was extensive t...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1984-04, Vol.69 (4), p.783-789
Main Authors: LUND, G, EINZIG, S, RYSAVY, J, BORGWARDT, B, SALOMONOWITZ, E, CRAGG, A, AMPLATZ, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cardiac Output - drug effects
Contrast Media - adverse effects
Diatrizoate - adverse effects
Dogs
Heart Rate - drug effects
Ischemia - physiopathology
Kidney Cortex - blood supply
Kidney Cortex - drug effects
Kidney Diseases - chemically induced
Kidneys
Medical sciences
Nephrology. Urinary tract diseases
Renal Circulation - drug effects
Urinary system involvement in other diseases. Miscellaneous
Citations: Items that cite this one
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Summary:Total and regional cortical blood flow was measured in dogs by the radioactive microsphere technique after renal damage of varying severity had been induced by combining selective injection of diatrizoate, iopamidol, or normal saline with a 10 min occlusion of the renal artery. There was extensive tubular and glomerular damage in the kidneys exposed to diatrizoate, but not in the kidneys exposed to saline. Iopamidol caused intermediate changes. Average cortical blood flow was reduced from baseline levels in all groups 5 min after perfusion was restored. After 1 hr the flow had returned to the baseline level. Analysis of variance did not show a statistically significant difference among the groups. A tendency for redistribution of flow from outer to inner cortical layers was seen, but this was present in all groups. The flow changes detected in this study cannot explain the varying severity of renal damage.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.69.4.783