Tiapamil, a new calcium antagonist: hemodynamic effects in patients with acute myocardial infarction

• Published in: Circulation (New York, N.Y.) N.Y.), 1985-04, Vol.71 (4), p.779-786
• Main Authors: EICHLER, H. G, MABIN, T. A, COMMERFORD, P. J, LLYOD, E. A, BECK, W, OPIE, L. H
• Format: Article
• Language: English
• Subjects: Antianginal agents. Coronary vasodilator agents; Arrhythmias, Cardiac - chemically induced; Biological and medical sciences; Calcium Channel Blockers - therapeutic use; Cardiovascular system; Clinical Trials as Topic; Coronary Disease - chemically induced; Double-Blind Method; Drug Therapy, Combination; Female; Heart Conduction System - drug effects; Hemodynamics - drug effects; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - drug therapy; Myocardial Infarction - metabolism; Myocardium - metabolism; Oxygen Consumption - drug effects; Pain - chemically induced; Pharmacology. Drug treatments; Propylamines - adverse effects; Propylamines - therapeutic use; Tiapamil Hydrochloride
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.71.4.779

The afterload reduction and myocardial oxygen sparing that results after administration of calcium antagonists suggests a possible role for these drugs in intervention after onset of acute myocardial infarction, but their use in this setting is limited by the possibility that left ventricular failure will develop. Tiapamil is a new verapamil congener. The hemodynamic effects of this drug (1 mg/kg followed by 25 micrograms/kg/min over 36 hr) were studied in 30 patients randomly assigned in a double-blind manner to a tiapamil or control group within 12 hr of the onset of acute myocardial infarction as diagnosed by Swan-Ganz catheterization and gated blood pool scans. Tiapamil reduced heart rate from 83 +/- 20 beats/min (mean +/- SD) before to 74 +/- 19 beats/min after drug (over an average 36 hr), arterial pressure from 128 +/- 22/87 +/- 14 to 118 +/- 16/74 +/- 11 mm Hg, rate-pressure product from 10,695 +/- 3492 to 8800 +/- 2550 units, and systemic vascular resistance from 1732 +/- 351 to 1400 +/- 350 dynes X sec X cm-5. Tiapamil also increased stroke volume index from 34.7 +/- 12.1 to 41.6 +/- 12.0 ml/m2, left ventricular ejection fraction from 50.1 +/- 14.8% to 56.4 +/- 17.4% (at 24 hr), left ventricular end-diastolic volume index from 71.3 +/- 23.1 to 80.5 +/- 23.7 ml/m2, and peak diastolic filling rate (an index of diastolic relaxation) from 2.1 +/- 0.9 to 2.6 +/- 0.8 end-diastolic volumes/sec (p less than .05 for all changes). Cardiac index, wedge pressure, left ventricular end-systolic volume, and PR interval remained unchanged.