Abstract 9590: Early Blood Lowering Effects of Renal Sympathetic Denervation

• Published in: Circulation (New York, N.Y.) N.Y.), 2011-11, Vol.124 (suppl_21)
• Main Authors: Plehn, Alexander, Holzapfel, Daniel, Raaz, Uwe, Schlitt, Axel, Dietz, Sebastian, Buerke, Michael, Hofmann, Britt, Markau, Silke, Girndt, Matthias, Werdan, Karl
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.124.suppl_21.A9590

Abstract only Introduction and Hypothesis Hypertension is a major global health problem. Renal sympathetic hyperactivity has been identified as a major contributor to the complex pathophysiology of hypertension. Catheter-based renal sympathetic denervation (RDN) has been shown to significantly reduce blood pressure (BP) in patients with severe hypertension. According to Symplicity HTN-1 and -2 trials it is known that the BP lowering effect will take about 1 to 6 month to develop. However, there is little information available on the immediate BP lowering effects of RDN. Our study carefully investigated early BP response to RDN in a cohort of patients with resistant hypertension (systolic BP >150 mm Hg on >3 antihypertensive drugs). Methods and Results Our study enrolled 28 consecutive patients (mean age 65 years, 48% women, 47% diabetic). Baseline values included a mean of 5.7 antihypertensive medications. A 24h Holter BP monitoring was recorded in every patient 24h before and after RDN. BP readings were then averaged according to daytime (7:00am-22:00pm), night (22:00pm-7:00am) and 24 hours intervals (figure 1). In treated patients mean averaged systolic BP was reduced by 15.3±3.34 mmHg (p