Abstract 11682: Prognostic Impact of Periodic Leg Movements in Hospitalized Heart Failure Patients

• Published in: Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A11682-A11682
• Main Authors: Kanno, Yuki, Yoshihisa, Akiomi, Takiguchi, Mai, Miura, Shunsuke, Sato, Akihiko, Shimizu, Takeshi, Nakamura, Yuichi, Yamauchi, Hiroyuki, Owada, Takashi, Abe, Satoshi, Suzuki, Satoshi, Oikawa, Masayoshi, Sakamoto, Nobuo, Yamaki, Takayoshi, Sugimoto, Koichi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Suzuki, Hitoshi, Saitoh, Shu-ichi, Takeishi, Yasuchika
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.132.suppl_3.11682

BackgroundPeriodic leg movements during sleep (PLMs) are the disorder characterized by regularly recurring movements of the legs during sleep. Recently, it has been reported that PLMs have a critical association with cardiovascular mortality and morbidity. However, the prevalence and impact of PLMs on cardiac and all-cause mortality still remain unclear in patients with heart failure (HF). Methods and ResultsConsecutive 114 patients admitted for treatment of HF and underwent polysomnography were divided into two groups based on PLM indexmoderate-severe PLMs group (PLM index ≥ 20/h, n = 24) and non-mild PLMs group (PLM index < 20/h, n = 90). We compared patient characteristics, findings of echocardiography and cardio-pulmonary exercise test between the two groups. Furthermore, we prospectively followed cardiac events including cardiac death and all-cause mortality. The moderate-severe PLMs group, as compared to non-mild PLMs groups, had lower levels of estimated GFR (46.8 vs. 59.5 ml/min/1.73cm, P = 0.032) and tended to have lower peak VO2 (14.5 vs. 16.3 ml/min/kg, P = 0.09). In contrast, age, body mass index, systolic blood pressure, B-type natriuretic peptide, hemoglobin, sodium, C-reactive protein and left ventricular ejection fraction were similar between the two groups. Importantly, cardiac mortality (log-rank P = 0.005) and all-cause mortality (P = 0.028) were higher in moderate-severe PLMs group than in non-mild PLMs group (Figure). In the multivariable Cox proportional hazard analyses, after adjusting for potential confounding factors, PLM index was an independent predictor of cardiac (HR 1.024, 95% CI 1.006-1.042, P = 0.009) and all-cause mortality (HR 1.016, 95% CI 1.001-1.031, P = 0.045) in HF patients. ConclusionsThe PLM index was a novel predictor of cardiac and all-cause mortality in HF patients.