Abstract 17054: Sex-Related Differences in Atherosclerosis Burden and Composition Evaluated by Magnetic Resonance: A Complex Interaction Between Visceral Adiposity and Atherogenic Lipoproteins

IntroductionVisceral adiposity increases the level of atherogenic lipoproteins and is linked to sex-related differences in cardiovascular risk. Hypothesis. Atherogenic lipoproteins could mediate the relationship between visceral fat and sex-related differences in atherosclerosis burden and compositi...

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Published in:Circulation (New York, N.Y.) N.Y.), 2018-11, Vol.138 (Suppl_1 Suppl 1), p.A17054-A17054
Main Authors: LeBlanc, Stéphanie, Coulombe, François, Bibeau, Karine, Bertrand, Olivier F, Pibarot, Philippe, Després, Jean-Pierre, Larose, Eric
Format: Article
Language:English
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Summary:IntroductionVisceral adiposity increases the level of atherogenic lipoproteins and is linked to sex-related differences in cardiovascular risk. Hypothesis. Atherogenic lipoproteins could mediate the relationship between visceral fat and sex-related differences in atherosclerosis burden and composition, including the lipid-rich necrotic core (LRNC).MethodsThis study included 294 women (39.4 ± 15.0 years) and 324 men (39.5 ± 13.8 years), matched for age and risk factors (hypertension, dyslipidemia, obesity, diabetes, smoking). Carotid atherosclerosis, visceral abdominal fat (VAT) and cardiac fat (CAT) were studied by magnetic resonance imaging.ResultsFor similar age and risk profile, women had less VAT (p
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.138.suppl_1.17054