Abstract 15189: Impact of Revascularization Strategy on the Prognosis of Young and Middle-aged Patients With Coronary Artery Disease

• Published in: Circulation (New York, N.Y.) N.Y.), 2020-11, Vol.142 (Suppl_3 Suppl 3), p.A15189-A15189
• Main Authors: Liu, Xiaoyan, Jin, Chengyue, Liu, Xinyu, Wang, Yong, Qiu, Hong
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.142.suppl_3.15189

IntroductionDespite increasing incidence and mortality of CAD among young and mid-age patients (age ≤ 65), the optimum revascularization strategy remains unclear. We compared outcomes of PCI and CABG in this patient group. Methods“Coronary artery bypass” and “percutaneous coronary intervention” were used to identify articles in PubMed and Cochrane database published prior to February 2, 2020. Both RCTs and observational studies (OSs) comparing PCI and CABG with data of patients or subgroups patients ≤ 65 years of age were included. The quality of study data was assessed by RoB2 and Newcastle-Ottawa Scale (NOS). The primary end point was all-cause mortality. Secondary endpoint includes MI, stroke, repeat revascularization (RR), and a composite endpoint of major adverse cardiac cerebral events (MACCE). We calculated odds ratio using Mantel-Haenszel method with random effects. ResultsA total of 10 RCTs and 20 OSs with 31226 CAD patients were included in our analysis, of which 1 RCT and 4 OSs focused on population ≤ 65 years old while the rest provided subgroup data. The risk of bias RCTs were low to middle, and quality ratings of OSs were 4-8 by NOS. Compared to CABG, PCI was associated with a higher risk of mortality (OR 1.42, 95% CI 1.24-1.62, P