Abstract 17257: Stroke Volume Reserve Index in HFrEF: A Non-Invasive Predictor of Early Clinical Outcomes and Marker of Inotropic Reserve

• Published in: Circulation (New York, N.Y.) N.Y.), 2020-11, Vol.142 (Suppl_3 Suppl 3), p.A17257-A17257
• Main Authors: Selevany, Ibrahim, Vaida, Florin, Adler, Eric D, Morris, Timothy, Kim, Paul
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.142.suppl_3.17257

IntroductionWe investigated whether stroke volume reserve index (SVRI), a novel non-invasive measure of inotropic reserve at submaximal exercise, would predict 1-year mortality and need for advanced therapies in heart-failure with reduced ejection fraction (HFrEF) patients. MethodsWe retrospectively studied a consecutive series of 245 ambulatory patients (57±11 years, 84% men) with HFrEF at a single center who underwent cardiopulmonary exercise testing (CPET) from January 2013 to December 2018. The primary outcome was defined as heart-transplantation, urgent left ventricular assist device (LVAD) implantation or death within 1 year of evaluation. SVRI was estimated at rest and at anaerobic threshold by VO2 (oxygen consumption)/pulse and previously validated estimates of C[a-v]O2 (arteriovenous difference in oxygen content). Multivariate regression selected the optimal predictors. ResultsAmong HFrEF patients studied, 82 (33.5%) deteriorated34 required heart-transplantation, 20 required LVADs and 28 died. SVRI of less than 130% was the best predictor of clinical deterioration (OR 3.98, p