Abstract 11484: Subclinical Renal Impairment and Inflammation in Cognitive Frailty in Older Adults (Tanushimaru Cohort Study)

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A11484-A11484
• Main Authors: Morikawa, Nagisa, Adachi, Hisashi, Enomoto, Mika, Fukami, Ako, Sakaue, Akiko, Maki, Yamamoto, Sato, Hiromi, Fukumoto, Yoshihiro
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.11484

IntroductionSarcopenia or slow gait speed (SGS) strongly interact with cognitive impairment (CI), that is cognitive frailty, possibly because of reinforcing common underlying pathophysiologies. We previously reported that renal impairment (RI) was associated with CI and inflammation is said to be important in the association. Associations of RI and inflammation with cognitive frailty has been understudied. HypothesisRI and inflammation are associated with cognitive frailty. MethodsWe conducted a cross-sectional study in 1368 population-based sample (mean age68.7±11.3 years, men:40.5%) of Tanushimaru, Japan in 2018. We measured urinary albumin-creatinine ratio (ACR) and high-sensitivity C-reactive protein (hsCRP) and assessed cognitive function by Mini-Mental State Examination (MMSE) and 5m walking time. RI was defined as ACR ≧30mg/dL and inflammation was defined as higher than median log-hsCRP. MMSE scores ≦27 out of 30-points was classified as CI and SGS was defined as