Abstract 6984: Cost Effectiveness of a 1-Hour High-Sensitivity Troponin-t Protocol in Suspected Acute Coronary Syndrome: A Trial-Based Analysis of the Rapid-tnt Randomised Trial

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A6984-A6984
• Main Authors: Chuang, Anthony, Gnanamanickam, Emmanuel, Lambrakis, Kristina, Horsfall, Matthew, Karnon, Jonathan, Blyth, Andrew, Seshadri, Anil, Nguyen, Mau, Briffa, Tom G, Cullen, Louise, Quinn, Stephen, French, John K, Chew, Derek P
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.6984

IntroductionTo better understand the economic impact of an accelerated 0/1-hour high-sensitivity troponin-T (hs-cTnT) protocol compared to conventional 0/3-hour protocol, we conducted a patient-level economic analysis of the RAPID-TnT randomised trial with a 12-month follow-up in patients presenting to emergency department (ED) with suspected acute coronary syndrome (ACS). MethodsAn economic evaluation was conducted with 3265 patients randomised to either the 0/1-hour hs-cTnT protocol (n=1634) or the conventional 0/3-hour protocol (n=1631). The primary outcome measure was a composite of all-cause mortality and new/recurrent myocardial infarction (MI). ResultsMean per patients costs were numerically higher in the 0/1-hour arm compared to the conventional 0/3-hour arm (by $1830.56/patient, 95% confidence interval [95%CI]$-1610.83 - 5271.96, P=0.30) with no statistically significant difference in primary outcome (0/1-hour62/1634 [3.8%], 0/3-hour82/1631 [5.0%], HR1.32 [95%CI095-1.83], P=0.1). The mean ED length of stay (LOS) was significantly lower in the 0/1-hour arm (by 0.63 hours/patient, 95%CI0.34-0.92, P