Abstract 9896: Demographics and Complications According to Amyloidosis Subtypes Light Chain Amyloidosis and Hereditary Transthyretin Amyloidosis

• Published in: Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (Suppl_1), p.A9896-A9896
• Main Authors: Ma, Jennifer, Ream, Sarah, Rodriguez, Tayana, Sarabia-Gonzalez, Alejandro, Alvarado, Luis, Dwivedi, Alok, Mukherjee, Debabrata
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.9896

IntroductionAmyloidosis is a multi-system disorder characterized by accumulation of misfolded proteins. The more common types are light chain amyloidosis (AL) and hereditary transthyretin amyloidosis (ATTR). We assess the demographics and complications of AL and ATTR subtypes for prompt recognition and treatment of this clinical entity. MethodsOur retrospective observational study analyzed the 2016 - 2018 National Inpatient Sample Databases for demographics (age, race, and gender), comorbidities (diabetes, hypertension, heart failure (HF), liver disease, pulmonary disease, coronary artery disease (CAD), and outcomes renal failure (RF), end-stage renal disease (ESRD) and mortality based on ICD-10 codes. Proportions were calculated, and unadjusted and adjusted associations of covariates according to amyloidosis subtype were determined using weight adjusted relative risk regression analyses. ResultsOf the total population, 0.17% (N=34,894) had amyloidosis. 733 patients were AL+, 118 ATTR+, and 34,043 were AL-, ATTR-. ATTR was more common in blacks, in older individuals and in males and had more CAD. However, HF, renal failure, ESRD (19.4% vs 2.54%, p