Abstract 12375: Gender-Related Differences in the Prognostic Value of Biomarkers in Patients With Acute Chest Pain Without Myocardial Infarction

IntroductionPatients presenting with acute chest pain may carry an increased risk of cardiovascular events even though myocardial infarction (MI) is excluded. Whether there are gender-related differences in the prognostic value of biomarkers in this patient population is unclear. MethodsWe performed...

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Published in:Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1), p.A12375-A12375
Main Authors: Myrmel, Gard M, Steiro, Ole-Thomas, Tjora, Hilde L, Langorgen, Jorund, Bjorneklett, Rune O, Skadberg, Oyvind, Bonarjee, Vernon, Mjelva, Øistein, Vikenes, Kjell, Omland, Torbjorn, Aakre, Kristin Moberg
Format: Article
Language:English
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Summary:IntroductionPatients presenting with acute chest pain may carry an increased risk of cardiovascular events even though myocardial infarction (MI) is excluded. Whether there are gender-related differences in the prognostic value of biomarkers in this patient population is unclear. MethodsWe performed a post hoc analysis of the WESTCOR trial that included 1319 patients (779 male and 540 female) admitted with acute chest pain without MI. Biomarkers included peak high sensitivity cardiac troponin T (hs-cTnT), peak high sensitivity cardiac troponin I (hs-cTnI), N-terminal proB-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15) and C-reactive protein (CRP), all from Roche Diagnostics. Cox regression analysis was performed for ln-transformed biomarkers in unadjusted models and models adjusting for age, hypercholesterolemia, current smoking, diabetes, hypertension, previous MI and eGFR
ISSN:0009-7322
1524-4539
DOI:10.1161/circ.146.suppl_1.12375