Abstract 14218: Social Isolation Decreases Survival and Worsens Cardiac Function in a Novel Murine Model of Coronary Atherosclerosis

• Published in: Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1), p.A14218-A14218
• Main Authors: Mullis, Danielle M, Wang, Hanjay, Zhu, Yuanjia, Bonham, Spencer, Padilla Lopez, Amanda S, Kocher, Olivier N, Krieger, Monty, Woo, Y. Joseph J
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.146.suppl_1.14218

IntroductionWith more people working from home after the COVID pandemic, it is of utmost importance to further understand the impact of social isolation on outcomes of patients with coronary atherosclerosis. Our preliminary studies have shown that the novel diet-inducible, fatal mouse model of coronary atherosclerosis, SR-BIΔCT/LDLR KO, tend to die on average around 4-6 weeks after starting a high-fat Paigan diet (HFD). This mouse model can be used to further understand the effect of social isolation on cardiovascular disease. We hypothesize that social isolation will decrease survival and worsen cardiac function. MethodsMale and female SR-BIΔCT/LDLR KO mice were put into social isolation (n=11), in a group of 2-3 (n=13), or in a group of 4-5 (n=22). At six-weeks-old, mice were started on a HFD to induce pathology. Echocardiography was performed to assess cardiac function. Analysis was performed using one-way Analysis of Variance tests and hoc-Tukey’s Honest Significant Difference tests. A log-rank test was used to calculate the difference in survival distributions. ResultsMice living in groups of 1, 2-3, and 4-5 lived for an average of 34.9, 35.6, and 41.5 days, respectively, after starting the HFD (Fig. 1A). The survival distribution is significantly different between the mice in isolation versus the mice in groups of 4-5 (p