Abstract 14864: Impact of Lifestyle and Cardiometabolic Risk Factors on Atherosclerotic Cardiovascular Diseases Incidence Across Body Weight Categories: A Prospective Study of 321,259 UK Biobank Participants

• Published in: Circulation (New York, N.Y.) N.Y.), 2022-11, Vol.146 (Suppl_1), p.A14864-A14864
• Main Authors: Paulin, Audrey, Manikpurage, Hasanga D, Despres, Jean-Pierre, Theriault, Sebastien, Arsenault, Benoit
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.146.suppl_1.14864

IntroductionIndividuals with an elevated body mass index (BMI) are at higher atherosclerotic cardiovascular diseases (ASCVD) risk. While the impact of an elevated BMI on ASCVD risk in individuals who are “metabolically healthy” is still debated, the respective contributions of BMI and actionable lifestyle and cardiometabolic risk factors on ASCVD risk remains largely unknown. We investigated the respective contributions of lifestyle and cardiometabolic risk factors and BMI to ASCVD incidence in apparently healthy individuals. MethodsWe developed a cardiovascular health score (CVHS) based on three lifestyle (smoking status, fruits and vegetables consumption and physical activity levels) and six cardiometabolic (blood pressure, HbA1c, LDL-C, HDL-C, C-Reactive Protein and triglyceride levels) parameters. The study sample included 321,259 participants of the UK Biobank, free of ASCVD recruited between 2006 and 2010. As of August 2021, 15,699 of them had incident ASCVD (fatal or nonfatal myocardial infarction, ischemic stroke or cardiac revascularization procedures. The impact of the CVHS on incident ASCVD alone and in BMI categories was assessed using Cox proportional hazards adjusted for age, sex, ethnicity and deprivation. ResultsCompared to participants with a very high CVHS (CVHS=9), those with a very low CVHS (CVHS=0) had a higher ASCVD risk (hazard ratio = 12.2 (95% CI, 6.7-22.2, p