Abstract P185: Disparities in Cardiovascular Disease and HIV Related Mortality in the United States

• Published in: Circulation (New York, N.Y.) N.Y.), 2023-02, Vol.147 (Suppl_1), p.AP185-AP185
• Main Authors: Ibrahim, Ramzi, Singh, Vikram J, Ravi, Soumiya, Singh, Simar J, Alabagi, Abdulla, Habib, Adam, Ferng, Jonathan, Khludenev, George, Salih, Mohammed, Lee, Justin Z
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.147.suppl_1.P185

IntroductionGreat strides have been made in microbiology and infectious diseases regarding HIV, revolutionizing the disease course. In the last forty years, advances in combination antiretroviral therapy (ART) have allowed HIV to become a chronic disease by dramatically decreasing the rates of acquired AIDS-defining illnesses. In contrast, a significant proportion of deaths in individuals infected with HIV due to cardiovascular events have been noted. HypothesisDisproportionate trends exist regarding CVD-related death within subpopulations of individuals infected with HIV in the United States (US). MethodsWe utilized the CDC Wide-ranging Online Data for Epidemiologic Research database to ascertain mortality data using death certificate information from the National Vital Statistics System. All CVD-related deaths (ICD10 CodesI00-I78) as the underlying cause of death and HIV (ICD10 CodeB20-B24) as the multiple causes of death from 1999 to 2020 were queried. The underlying cause of death is defined as the disease that directly led to death and multiple causes of death were defined as the diseases that contributed to death. Data were represented as age-adjusted mortality rates (AAMR) per 100,000 population and 95% confidence intervals, stratified by gender, racial, and geographic subgroups. Joinpoint regression (National Cancer Institute) was utilized for trend analysis and average annual percentage change (AAPC) calculation. ResultsA total of 8,950 deaths were observed from 1999 to 2020. AAMR increased from 0.10 in 1999 to 0.15 in 2020 (p