Abstract 313: Protective Effects of Iron-Restricted Food against Diabetic Nephropathy in db/db Mice

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-09, Vol.60 (suppl_1)
• Main Authors: Enomoto, Hideaki, Ikeda, Yasumasa, Tajima, Soichiro, Izawa-Ishizawa, Yuki, Kihira, Yoshitaka, Ishizawa, Keisuke, Tomita, Shuhei, Tsuchiya, Koichiro, Tamaki, Toshiaki
• Format: Article
• Language: English
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.60.suppl_1.A313

Abstract only Background: Iron, an essential trace metal for organisms, catalyzes highly toxic hydroxyl radical via Fenton/Haber-Weiss reaction. We recently have clarified that iron chelation prevents the development of adipocyte hypertrophy through the reduction of oxidative stress in diabetic obese mice. It is suggested that iron reduction potentiates to be beneficial effects against diabetic complications. In the present study, we investigated the protective action of iron restriction against the progression of diabetic nephropathy. METHODS: We employed and divided male db/db mice of 8 weeks old age, a model of diabetic nephropathy, into 2 groups, normal diet group (Fe 100mg/kg food; ND) and low iron diet group (Fe 10mg/kg food; LID). After 8 weeks treatment, the mice were used for analysis. Results: LID group showed the decreased renal iron content (7.5±3.0 μg/g tissue vs 5.7±0.3 μg/g tissue, ND vs LID, p