Abstract 129: In Defense of Clinic Blood Pressure

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-09, Vol.70 (suppl_1)
• Main Authors: Kidambi, Srividya, Chelius, Thomas, Nunuk, Irene, Ding, Yue, Obi, Brittaney, Jain, Sumeet, Mattson, David, Cowley, Allen, Laud, Purushottam, Wang, Tao, Kotchen, Jane, Liang, Mingyu, Kotchen, Theodore
• Format: Article
• Language: English
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.70.suppl_1.129

Abstract only For genetic studies of hypertension, between 1994 and 2006, we established a cohort of 2,639 African Americans (53% female), 51% of whom were hypertensive (H). The purpose of this report is twofold: a) to evaluate the relationship of baseline hypertension status and blood pressure (BP) level with subsequent mortality in this cohort; and b) to compare the relationship of clinic and 24-hour BPs with the subsequent incidence of fatal and non-fatal cardiovascular (CV) events in a subset of the original cohort. Clinic BP was obtained in triplicate in all 2,369 subjects as part of screening procedures for a 3-day inpatient clinical study of a sub-sample (n=266). BP medications were discontinued for 1-week after the screening visit and prior to inpatient study. Detailed phenotyping along with 24-hour BPs were obtained during the 3-day study. Compared to normotensives (N) at baseline, H had higher standardized clinic BP (145 ± 20 [SD] / 94 ± 13 vs 118 ± 10/ 76 ± 8 mm Hg), were slightly older (45 ± 7 vs 42 ± 7 years; p