Abstract 016: GRN Gene Mutation Leads To Vascular Abnormalities Via Mitochondrial Dysfunction And Oxidative Stress

Abstract only Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Loss of contractility of vascular smooth muscle cells (VSMC) is a major factor of CVD. The GRN gene encodes the glycoprotein progranulin (PGRN). Ubiquitously expressed, PGRN is implicated in anti-inflamma...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2023-09, Vol.80 (Suppl_1)
Main Authors: Singh, Shubhnita, Bruder do Nascimento, Ariane, Costa, Rafael M, Bharathi, Sivakama S, Goetzman, Eric, Bruder, Thiago
Format: Article
Language:English
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