Abstract 813: Downregulation of the Cardiac Sodium Channel Nav1.5 Mediates Obesity-Induced Atrial Fibrillation

Abstract only Background: Obesity increases atrial fibrillation (AF) risk, but the underlying mechanisms are unclear. Emerging evidence supports reduced cardiac Na + channel (Nav1.5) expression and current ( I Na ) as one potential mechanism. Objective: We used an acquired (diet-induced obese, DIO)...

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Published in:Circulation research 2019-08, Vol.125 (Suppl_1)
Main Authors: Sridhar, Arvind, McCauley, Mark, Hong, Liang, Menon, Ambili, Perike, Srikanth, Zhang, Meihong, Ai, Xun, Yan, JiaJie, Youn, Seock-Won, da Silva, Ivson Bezerra, Bonini, Marcelo, Rehman, Jalees, Darbar, Dawood
Format: Article
Language:English
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Summary:Abstract only Background: Obesity increases atrial fibrillation (AF) risk, but the underlying mechanisms are unclear. Emerging evidence supports reduced cardiac Na + channel (Nav1.5) expression and current ( I Na ) as one potential mechanism. Objective: We used an acquired (diet-induced obese, DIO) obese mouse model to test the hypothesis that obesity increases AF risk by downregulating Nav1.5. Methods: Weight, BP, plasma glucose, and F 2 -isoprostanes were measured in DIO mice and compared to controls. Echocardiography, EP studies, immunohistochemistry, Western blotting, cellular patch clamping and optical mapping studies were performed. Results: DIO (37.5±3.8) mice were heavier than controls ( 24.3 ±4.1;P
ISSN:0009-7330
1524-4571
DOI:10.1161/res.125.suppl_1.813