Abstract WP191: Genetic Analyses Support A Causal Role Of Lung Cancer In Ischemic Stroke

• Published in: Stroke (1970) 2022-02, Vol.53 (Suppl_1), p.AWP191-AWP191
• Main Authors: Vanent, Kevin N, Acosta, Julian N, Both, Cameron, Leasure, Audrey C, Torres Lopez, Victor, Szejko, Natalia, Rivier, Cyprien, de Havenon, Adam H, Sharma, Richa, Levitt, Michael R, Sheth, Kevin N, Falcone, Guido J
• Format: Article
• Language: English
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/str.53.suppl_1.WP191

IntroductionLung cancer has been linked to increased risk of thromboembolic events, including stroke. However, a causal relationship between lung cancer and ischemic stroke (IS) has yet to be established. MethodsWe conducted a two-stage study using observational and genetic data from the UK Biobank, a large cohort study that enrolled over 500,000 Britons aged 40-69. We included participants of European descent. In Stage I, we used logistic regression to test the association between self-reported / ICD-defined lung cancer and risk of IS. In Stage II, we constructed a polygenic risk score (PRS) using 31 independent genetic variants known to associate with lung cancer, fitted logistic regression to assess the relationship between this PRS and risk of IS, and implemented the inverse variance weighted method of Mendelian randomization (MR). We tested for horizontal pleiotropy using the MR-Egger and MR Pleiotropy Residual Sum and Outlier (MR-PRESSO) approaches. ResultsOut of 409,629 participants of European descent enrolled in the UK Biobank, there were 5,060 IS cases (mean age, 61.6 [standard deviation 6.5]; female sex, 1813 [35.8%]). The prevalence of lung cancer was 1.9% (n=94) and 0.5% (n=1,961) among persons with and without IS, respectively (unadjusted p