Characterising the contribution of auditory and somatosensory inputs to TMS-evoked potentials following stimulation of prefrontal, premotor, and parietal cortex

Transcranial magnetic stimulation (TMS) results in a series of deflections in electroencephalography (EEG) recordings known as a TMS-evoked potential (TEP). However, it remains unclear whether these responses reflect neural activity resulting from transcranial stimulation of the cortex, the sensory...

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Bibliographic Details
Published in:Imaging neuroscience (Cambridge, Mass.) Mass.), 2024-11, Vol.2, p.1-23
Main Authors: Biabani, Mana, Fornito, Alex, Goldsworthy, Mitchell, Thompson, Sarah, Graetz, Lynton, Semmler, John G., Opie, George M., Bellgrove, Mark A., Rogasch, Nigel C.
Format: Article
Language:English
Subjects:
auditory
dorsolateral prefrontal cortex
electroencephalography
muscle
parietal cortex
premotor cortex
sensory
somatosensory
TMS-evoked potentials
transcranial magnetic stimulation
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Summary:Transcranial magnetic stimulation (TMS) results in a series of deflections in electroencephalography (EEG) recordings known as a TMS-evoked potential (TEP). However, it remains unclear whether these responses reflect neural activity resulting from transcranial stimulation of the cortex, the sensory experiences of TMS, or a combination of the two. Across three experiments (total n = 135), we recorded EEG activity following TMS to the dorsolateral prefrontal cortex, premotor cortex, and parietal cortex as well as a sensory control condition (stimulation of the shoulder or electrical stimulation of the scalp with a click sound). We found that TEPs showed a stereotypical frontocentral N100/P200 complex following TMS of all cortical sites and control conditions, regardless of TMS intensity or the type of sensory control. In contrast, earlier TEPs (
ISSN:2837-6056
2837-6056
DOI:10.1162/imag_a_00349