Serum homocysteine is associated with the severity of primary chronic venous disease

Objective This study was conducted to assess whether serum homocysteine concentration was associated with the severity of primary chronic venous disease. Design Cross-sectional study. Methods A total of 282 primary chronic venous disease patients were enrolled from outpatient vascular services. The...

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Bibliographic Details
Published in:Phlebology 2016-07, Vol.31 (6), p.409-415
Main Authors: Smith, Ross K, Quigley, Frank, Tosenovsky, Patrik, Velu, Ramesh, Bradshaw, Barbara, Buettner, Petra, Golledge, Jonathan
Format: Article
Language:English
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Summary:Objective This study was conducted to assess whether serum homocysteine concentration was associated with the severity of primary chronic venous disease. Design Cross-sectional study. Methods A total of 282 primary chronic venous disease patients were enrolled from outpatient vascular services. The severity of venous disease was graded using the Clinical Etiology Anatomy Pathophysiology classification system. The association of serum homocysteine concentration with advanced primary chronic venous disease (C4-6) was assessed using the Mann Whitney U test and logistic regression analysis. Results Median (interquartile range) serum homocysteine concentrations were 9.10 µM (7.55–10.75) and 10.40 µM (8.85–13.10) in patients with primary chronic venous disease classified by C1-3 (n = 209) and C4-6 (n = 73) grades, respectively, p 
ISSN:0268-3555
1758-1125
DOI:10.1177/0268355515592076