Homocysteine, Vitamin B 12 and Folic Acid Levels in Psoriatic Patients and Correlation with Disease Severity

Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Th...

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Published in:International journal of immunopathology and pharmacology 2010-07, Vol.23 (3), p.911-916
Main Authors: Brazzelli, V., Grasso, V., Fornara, L., Moggio, E., Gamba, G., Villani, S., Borroni, G.
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container_title International journal of immunopathology and pharmacology
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creator Brazzelli, V.
Grasso, V.
Fornara, L.
Moggio, E.
Gamba, G.
Villani, S.
Borroni, G.
description Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B 12 and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p
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The severity of psoriasis assessed according to PASI (19.51±16.26) did not directly correlate either with higher levels of homocysteine or with vitamin B 12 and folic acid plasma levels. In conclusion, a significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. A significant correlation between hyperhomocysteinaemia and lower vitamin B 12 levels, but not folic acid, was evidenced. 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The severity of psoriasis assessed according to PASI (19.51±16.26) did not directly correlate either with higher levels of homocysteine or with vitamin B 12 and folic acid plasma levels. In conclusion, a significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. A significant correlation between hyperhomocysteinaemia and lower vitamin B 12 levels, but not folic acid, was evidenced. 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title Homocysteine, Vitamin B 12 and Folic Acid Levels in Psoriatic Patients and Correlation with Disease Severity
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