Intranasal Dexmedetomidine for Procedural Sedation in Infants: A Retrospective Study

Background: Infants undergoing magnetic resonance imaging (MRI) often require pharmacological sedation. Dexmedetomidine is an alpha-2 receptor agonist frequently used to sedate children and infants because the neonatologist can easily adjust the sedation depth, the patient maintains spontaneous brea...

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Bibliographic Details
Published in:Journal of neonatology 2025-01
Main Authors: Dini, Gianluca, Celi, Federica, Santini, Maria Grazia, Semeraro, Carla Maria
Format: Article
Language:English
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Summary:Background: Infants undergoing magnetic resonance imaging (MRI) often require pharmacological sedation. Dexmedetomidine is an alpha-2 receptor agonist frequently used to sedate children and infants because the neonatologist can easily adjust the sedation depth, the patient maintains spontaneous breathing and awakens rapidly afterwards. Objective: This study evaluates whether dexmedetomidine can be safely used as the sole sedative for preterm and term-born infants less than 80 weeks of postmenstrual age (PMA) undergoing diagnostic procedures. Methods: We conducted a retrospective, single-center analysis of 50 preterm and term-born infants (
ISSN:0973-2179
0973-2187
DOI:10.1177/09732179241307121