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Oxaliplatin-Induced Renal Tubular Vacuolization
Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-ol...
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| Published in: | The Annals of pharmacotherapy 2014-06, Vol.48 (6), p.796-800 |
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| container_title | The Annals of pharmacotherapy |
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| creator | Yaghobi Joybari, Ali Sarbaz, Samaneh Azadeh, Payam Mirafsharieh, S. Abbas Rahbari, Ali Farasatinasab, Maryam Mokhtari, Majid |
| description | Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-old woman with colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle of oxaliplatin chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect hyperbilirubinemia, and high lactate dehydrogenase. A negative direct antiglobulin test and presence of |
| doi_str_mv | 10.1177/1060028014526160 |
| format | article |
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Abbas ; Rahbari, Ali ; Farasatinasab, Maryam ; Mokhtari, Majid</creator><creatorcontrib>Yaghobi Joybari, Ali ; Sarbaz, Samaneh ; Azadeh, Payam ; Mirafsharieh, S. Abbas ; Rahbari, Ali ; Farasatinasab, Maryam ; Mokhtari, Majid</creatorcontrib><description>Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-old woman with colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle of oxaliplatin chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect hyperbilirubinemia, and high lactate dehydrogenase. A negative direct antiglobulin test and presence of <1% schistocytes in the peripheral blood smear stood against the diagnosis of immune-mediated hemolytic anemia or hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. Renal biopsy was consistent with interstitial nephritis with tubular vacuolization in favor of drug-induced renal injury. Based on the Naranjo Probability Scale, the likelihood of oxaliplatin-induced renal injury in this case was probable. Discussion: To our knowledge, this is the first case report of renal tubular vacuolization with symptoms mimicking thrombotic microangiopathy in a patient on long-term chemotherapy with oxaliplatin. Conclusions: Oxaliplatin can induce various forms of nephrotoxicity such as renal tubular vacuolization, acute tubular necrosis, renal tubular acidosis, and acute kidney injury secondary to hematological toxicity. Monitoring for renal function abnormalities and hemolysis should be considered during oxaliplatin-based chemotherapy.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1177/1060028014526160</identifier><identifier>PMID: 24615628</identifier><identifier>CODEN: APHRER</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adenocarcinoma - drug therapy ; Adult ; Anemias. Hemoglobinopathies ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Colonic Neoplasms - drug therapy ; Diseases of red blood cells ; Female ; Hematologic and hematopoietic diseases ; Humans ; Kidney - pathology ; Kidney Diseases - chemically induced ; Kidney Diseases - pathology ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Organoplatinum Compounds - adverse effects ; Pharmacology. Drug treatments ; Platelet diseases and coagulopathies ; Renal failure</subject><ispartof>The Annals of pharmacotherapy, 2014-06, Vol.48 (6), p.796-800</ispartof><rights>The Author(s) 2014</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-85baf9537bbcf81852ad51d8d63cc0a4f97a5b057fba7c0e217b55d89817675b3</citedby><cites>FETCH-LOGICAL-c433t-85baf9537bbcf81852ad51d8d63cc0a4f97a5b057fba7c0e217b55d89817675b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28468427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24615628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaghobi Joybari, Ali</creatorcontrib><creatorcontrib>Sarbaz, Samaneh</creatorcontrib><creatorcontrib>Azadeh, Payam</creatorcontrib><creatorcontrib>Mirafsharieh, S. Abbas</creatorcontrib><creatorcontrib>Rahbari, Ali</creatorcontrib><creatorcontrib>Farasatinasab, Maryam</creatorcontrib><creatorcontrib>Mokhtari, Majid</creatorcontrib><title>Oxaliplatin-Induced Renal Tubular Vacuolization</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-old woman with colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle of oxaliplatin chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect hyperbilirubinemia, and high lactate dehydrogenase. A negative direct antiglobulin test and presence of <1% schistocytes in the peripheral blood smear stood against the diagnosis of immune-mediated hemolytic anemia or hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. Renal biopsy was consistent with interstitial nephritis with tubular vacuolization in favor of drug-induced renal injury. Based on the Naranjo Probability Scale, the likelihood of oxaliplatin-induced renal injury in this case was probable. Discussion: To our knowledge, this is the first case report of renal tubular vacuolization with symptoms mimicking thrombotic microangiopathy in a patient on long-term chemotherapy with oxaliplatin. Conclusions: Oxaliplatin can induce various forms of nephrotoxicity such as renal tubular vacuolization, acute tubular necrosis, renal tubular acidosis, and acute kidney injury secondary to hematological toxicity. Monitoring for renal function abnormalities and hemolysis should be considered during oxaliplatin-based chemotherapy.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adult</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - pathology</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Organoplatinum Compounds - adverse effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet diseases and coagulopathies</subject><subject>Renal failure</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Lw0AQxRdRbK3ePUkvHtfObPYrRylWC4WCVK9hdrORlDQp2QbUv96UVgXB0wy835vhPcauEe4QjZkgaABhAaUSGjWcsCEqKbgWBk77vZf5Xh-wixjXAJCiSM_ZQEiNSgs7ZJPlO1XltqJdWfN5nXc-5OPnUFM1XnWuq6gdv5Lvmqr87JGmvmRnBVUxXB3niL3MHlbTJ75YPs6n9wvuZZLsuFWOilQlxjlfWLRKUK4wt7lOvAeSRWpIOVCmcGQ8BIHGKZXb1KLRRrlkxOBw17dNjG0osm1bbqj9yBCyffbsb_becnOwbDu3CfmP4TtsD9weAYqeqqKl2pfxl7NSWylMz_EDF-ktZOuma_s64v-PvwAnimzT</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Yaghobi Joybari, Ali</creator><creator>Sarbaz, Samaneh</creator><creator>Azadeh, Payam</creator><creator>Mirafsharieh, S. Abbas</creator><creator>Rahbari, Ali</creator><creator>Farasatinasab, Maryam</creator><creator>Mokhtari, Majid</creator><general>SAGE Publications</general><general>Whitney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140601</creationdate><title>Oxaliplatin-Induced Renal Tubular Vacuolization</title><author>Yaghobi Joybari, Ali ; Sarbaz, Samaneh ; Azadeh, Payam ; Mirafsharieh, S. Abbas ; Rahbari, Ali ; Farasatinasab, Maryam ; Mokhtari, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-85baf9537bbcf81852ad51d8d63cc0a4f97a5b057fba7c0e217b55d89817675b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adult</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - pathology</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Organoplatinum Compounds - adverse effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet diseases and coagulopathies</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaghobi Joybari, Ali</creatorcontrib><creatorcontrib>Sarbaz, Samaneh</creatorcontrib><creatorcontrib>Azadeh, Payam</creatorcontrib><creatorcontrib>Mirafsharieh, S. Abbas</creatorcontrib><creatorcontrib>Rahbari, Ali</creatorcontrib><creatorcontrib>Farasatinasab, Maryam</creatorcontrib><creatorcontrib>Mokhtari, Majid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaghobi Joybari, Ali</au><au>Sarbaz, Samaneh</au><au>Azadeh, Payam</au><au>Mirafsharieh, S. Abbas</au><au>Rahbari, Ali</au><au>Farasatinasab, Maryam</au><au>Mokhtari, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxaliplatin-Induced Renal Tubular Vacuolization</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>48</volume><issue>6</issue><spage>796</spage><epage>800</epage><pages>796-800</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><coden>APHRER</coden><abstract>Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-old woman with colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle of oxaliplatin chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect hyperbilirubinemia, and high lactate dehydrogenase. A negative direct antiglobulin test and presence of <1% schistocytes in the peripheral blood smear stood against the diagnosis of immune-mediated hemolytic anemia or hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. Renal biopsy was consistent with interstitial nephritis with tubular vacuolization in favor of drug-induced renal injury. Based on the Naranjo Probability Scale, the likelihood of oxaliplatin-induced renal injury in this case was probable. Discussion: To our knowledge, this is the first case report of renal tubular vacuolization with symptoms mimicking thrombotic microangiopathy in a patient on long-term chemotherapy with oxaliplatin. Conclusions: Oxaliplatin can induce various forms of nephrotoxicity such as renal tubular vacuolization, acute tubular necrosis, renal tubular acidosis, and acute kidney injury secondary to hematological toxicity. Monitoring for renal function abnormalities and hemolysis should be considered during oxaliplatin-based chemotherapy.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>24615628</pmid><doi>10.1177/1060028014526160</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Annals of pharmacotherapy, 2014-06, Vol.48 (6), p.796-800 |
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| subjects | Adenocarcinoma - drug therapy Adult Anemias. Hemoglobinopathies Antineoplastic Agents - adverse effects Biological and medical sciences Colonic Neoplasms - drug therapy Diseases of red blood cells Female Hematologic and hematopoietic diseases Humans Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - pathology Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Organoplatinum Compounds - adverse effects Pharmacology. Drug treatments Platelet diseases and coagulopathies Renal failure |
| title | Oxaliplatin-Induced Renal Tubular Vacuolization |
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