Nevirapine-based antiretroviral therapy started early in the course of tuberculosis treatment in adult Malawians

The tuberculosis (TB) mortality rate of registered TB patients in Malawi is 23%, and 59% of the deaths occur in the first 2 months of treatment. HIV-related complications appear to be an important cause. Starting antiretroviral therapy early during tuberculosis treatment may improve outcome but prob...

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Bibliographic Details
Published in:Antiviral therapy 2007-01, Vol.12 (4), p.515-521
Main Authors: VAN OOSTERHOUT, Joep J. G, KUMWENDA, Johnstone J, BEADSWORTH, Michael, MATEYU, Gabriel, LONGWE, Temba, BURGER, David M, ZIJLSTRA, Eduard E
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - drug therapy
AIDS-Related Opportunistic Infections - microbiology
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - administration & dosage
Antitubercular Agents - therapeutic use
Antiviral agents
Bacterial diseases
Biological and medical sciences
Drug Administration Schedule
Drug Therapy, Combination
HIV Infections - complications
HIV Infections - drug therapy
HIV-1 - drug effects
HIV-1 - physiology
Human bacterial diseases
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Lamivudine - administration & dosage
Lamivudine - therapeutic use
Malawi
Medical sciences
Middle Aged
Nevirapine - administration & dosage
Nevirapine - therapeutic use
Pharmacology. Drug treatments
Reverse Transcriptase Inhibitors - administration & dosage
Reverse Transcriptase Inhibitors - therapeutic use
Rifampin - administration & dosage
Rifampin - therapeutic use
Stavudine - administration & dosage
Stavudine - therapeutic use
Treatment Outcome
Tuberculosis - complications
Tuberculosis - drug therapy
Tuberculosis and atypical mycobacterial infections
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:The tuberculosis (TB) mortality rate of registered TB patients in Malawi is 23%, and 59% of the deaths occur in the first 2 months of treatment. HIV-related complications appear to be an important cause. Starting antiretroviral therapy early during tuberculosis treatment may improve outcome but problems often arise with drug interactions, adherence, toxicity and immune reconstitution disease (IRD). We prospectively followed 27 HIV-infected adult Malawians after starting Triomune (a generic fixed drug combination of stavudine, lamivudine and nevirapine) in the second week of tuberculosis treatment. At baseline, 88% had CD4+ T-cell counts
ISSN:1359-6535
2040-2058
DOI:10.1177/135965350701200406