Documented Fungal Infections after Prophylaxis or Therapy with Wide Spectrum Antibiotics: Relationship Between Certain Fungal Pathogens and Particular Antimicrobials?

Antibiotics are known to be one of the major risk factors for fungal infection. We investigated whether there was a relationship between particular documented fungal infections and therapeutically or prophylactically administered antimicrobials in 105 patients with fungemia or histologically proven...

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Published in:Journal of chemotherapy (Florence) 1999-10, Vol.11 (5), p.385-390
Main Authors: Krčméry, V., Matejička, F., PichňovÁ, E., Jurga, Ĺ., Sulcova, M., Kunová, A., West, D.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - adverse effects
Biological and medical sciences
Fungemia - chemically induced
Human mycoses
Humans
Infectious diseases
Medical sciences
Miscellaneous mycoses
Mycoses
Mycoses - chemically induced
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Summary:Antibiotics are known to be one of the major risk factors for fungal infection. We investigated whether there was a relationship between particular documented fungal infections and therapeutically or prophylactically administered antimicrobials in 105 patients with fungemia or histologically proven invasive aspergillosis or fusariosis. Out of 105 patients, 82.9% received antimicrobials affecting anaerobic microbial gut flora such as: imipenem, vancomycin, ceftazidime, metronidazole, clindamycin or ampicillin-sulbactam. In addition, 44.5% of patients had received prophylaxis with ofloxacin. 31.5% of Candida albicans fungemias occurred despite empiric therapy with amphotericin B and 21.1% during prophylaxis with azoles. The incidence of C. albicans infections (fungemias) was significantly higher (58.9% vs 33.7%, p
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.1999.11.5.385