Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Background: Acute lymphoblastic leukemia (ALL) is a malignant disorder with a long-term remission of less than 50% of adult patients and of nearly 80% of children. Relapsed and refractory (r/r) adult and childhood B-ALL patients, have significant unmet medical needs. Adoptive transfer of patient-der...

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Bibliographic Details
Published in:	Blood 2018-11, Vol.132 (Supplement 1), p.196-196
Main Authors:	Gaipa, Giuseppe, Magnani, Chiara Francesca, Belotti, Daniela, Matera, Giada, Tettamanti, Sarah, Cabiati, Benedetta, Cesana, Stefania, Colombo, Valentina, Cazzaniga, Giovanni, Fazio, Grazia, Buracchi, Chiara, Rigamonti, Silvia, Rovelli, Attilio, Balduzzi, Adriana, Napolitano, Sara, Montini, Eugenio, Borleri, Gian Maria, Gritti, Giuseppe, Lussana, Federico, Introna, Martino, Rambaldi, Alessandro, Dastoli, Giuseppe, Biondi, Andrea
Format:	Article
Language:	English
Online Access:	Get full text
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