Platelet Dysfunction Detected Using Rotational Thromboelastometry (ROTEM) in Severely Thrombocytopenic Patients with a Bleeding Phenotype

Background: Thrombocytopenia occurs reasonably frequently with the underlying causes being numerous and requiring time to delineate. Patients may present with active bleeding or low platelet counts may be detected incidentally. Treatments are varied, refractory cases are not uncommon, and in those w...

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Bibliographic Details
Published in:Blood 2019-11, Vol.134 (Supplement_1), p.2357-2357
Main Authors: Choi, Philip Young-Ill, Hicks, Sarah, Gardiner, Elizabeth E., Crispin, Philip, Slade, James, D'Rozario, James, Parish, Christopher, Coupland, Lucy
Format: Article
Language:English
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Summary:Background: Thrombocytopenia occurs reasonably frequently with the underlying causes being numerous and requiring time to delineate. Patients may present with active bleeding or low platelet counts may be detected incidentally. Treatments are varied, refractory cases are not uncommon, and in those who do respond, relapses occur. The clinician's principal concern is to limit the risk of a life-threatening hemorrhage, however, the platelet count is an unreliable predictor of bleeding risk. Adult patients presenting with platelet counts < 20 x 109/L present the greatest safety dilemma for clinicians. Previous studies using ROTEM in adult ITP patients with platelet counts < 60 x 109/L and paediatric cases with platelet counts < 30 x 109/L demonstrated that clot firmness parameters correlated with bleeding score1. Our aim, therefore, was to perform ROTEM analysis on patients with a platelet count
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-132232