Defibrotide: Real World Experience for Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplantation

• Published in: Blood 2020-11, Vol.136 (Supplement 1), p.23-24
• Main Authors: Nauffal, Mary, Kim, Haesook T., Richardson, Paul G., Soiffer, Robert J., Antin, Joseph H., Cutler, Corey, Nikiforow, Sarah, Gooptu, Mahasweta, Koreth, John, Shapiro, Roman M, Romee, Rizwan, Ho, Vincent T.
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood-2020-135895

Introduction: Veno-occlusive disease/sinusoidal obstructive syndrome (VOD/SOS) is a potentially life-threatening complication after hematopoietic cell transplant (HCT). Defibrotide (DF), a mixture of single and double stranded oligonucleotides with profibrinolytic, anti-thrombotic, anti-ischemic and anti-inflammatory activity was approved by the FDA for the treatment of VOD/SOS in 2016. Prior to its FDA approval, its use was mostly restricted to patients with moderate to severe VOD characterized by multiorgan dysfunction. However, following approval, it has been used more liberally. We herein report a “real world experience” for commercially available DF in patients who developed VOD/SOS at our transplant center. Methods: All patients who received DF for the treatment of VOD/SOS after allogeneic HCT from March 2016 until June 2019 were included in this study. Baseline demographic data were retrieved from the Dana Farber Cancer Institute BMT repository, and chart review was performed to obtain additional information for cases. All received DF 6.25 mg/kg/dose every 6 hours for 21-day cycle for the treatment of VOD/SOS. Patients were diagnosed with VOD/SOS if they met at least 2 of the EBMT criteria; total bilirubin ≥ 2mg/dL, painful hepatomegaly, ascites, weight gain >5% or ultrasonographic evidence of VOD. VOD/SOS severity grading was defined per the EBMT VOD guidelines. Results: Twenty-eight patients received DF for the management of VOD/SOS. Of these, 12, 8, and 8 patients had mild-moderate, severe, and very severe VOD/SOS respectively. Median time to diagnosis of VOD/SOS was day +25 after HCT. Five cases were confirmed by liver biopsy and 16 patients had reversal of flow on ultrasound. Twelve and 16 patients received myeloablative and non-myeloablative regimens respectively. DF was started on the day of diagnosis in 71% of patients. Four patients had received inotuzumab ozogamicin prior to VOD/SOS diagnosis. Twenty-one (75%) patients had resolution of VOD/ SOS, defined by complete resolution of clinical symptoms and improvement of laboratory data ascertained via detailed chart review, at a median of 14 days from starting DF. Patients with very severe VOD/SOS took the longest to respond at a median of 21 days as compared to 10 and 11.5 days in the mild-moderate and severe group, respectively (P=0.04). Survival at 28 and 56 days from VOD/SOS diagnosis was 82% and 71% respectively. In univariable analysis, the presence of pulmonary dysfunction (PD) at VOD/S