Conditioning Regimens and Outcomes after Allogeneic Hematopoietic Cell Transplant for Hyperinflammatory Inborn Errors of Immunity

Introduction: Inborn errors of immunity such as hemophagocytic lymphohistiocytosis (HLH) and chronic granulomatous disease (CGD) are characterized by hyperinflammation. Hematopoietic cell transplantation (HCT) in the setting of hyperinflammation leads to high morbidity and mortality. Consequently, t...

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Bibliographic Details
Published in:Blood 2020-11, Vol.136 (Supplement 1), p.36-37
Main Authors: Marsh, Rebecca A., Kim, Soyoung, Hebert, Kyle, Dvorak, Christopher C., Aquino, Victor, Baker, K. Scott Scott, Chellapandian, Deepak, Davila, Blachy, Duncan, Christine, Eckrich, Michael J., Georges, George E., Olson, Timothy S., Pulsipher, Michael A, Shenoy, Shalini, Stenger, Elizabeth, Vander Lugt, Mark, Yu, Lolie C., Gennery, Andrew, Eapen, Mary
Format: Article
Language:English
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Summary:Introduction: Inborn errors of immunity such as hemophagocytic lymphohistiocytosis (HLH) and chronic granulomatous disease (CGD) are characterized by hyperinflammation. Hematopoietic cell transplantation (HCT) in the setting of hyperinflammation leads to high morbidity and mortality. Consequently, there is increasing use of less intense conditioning regimens, which can increase risk of mixed chimerism or graft failure. We sought to study the effect of common regimens on outcomes after HCT using data reported to the Center for International Blood and Marrow Transplant Research. Methods: 365 patients aged
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2020-139930