Loading…

Influence of Activated Protein C Resistance on Short-Term Hospital Outcomes Following Admission for Acute Ischemic Stroke in the United States

Introduction: Activated protein C (APC) plays a crucial role in breaking down factor Va and VIIIa, preventing excessive blood clotting. APC resistance occurs when protein C is unable to degrade these factors, leading to a higher risk of thrombosis. This condition can be either hereditary or acquired...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2023-11, Vol.142 (Supplement 1), p.5487-5487
Main Authors: Ajitha, Salini, Adla Jala, Saisree Reddy, Chennapragada, Suma Sri, Dandwani, Mehndi, Savani, Saloni, Singh, Vaishnavi, Pramudita, Arcita Hanjani, Aggarwal, Shruti, Aisha, Fnu, Sombans, Shaheen, Pekyi-Boateng, Prince Kwabla, Goyal, Shriya, Thevuthasan, Sindhu, Ramphul, Yogeshwaree, Sakthivel, Hemamalini, Ramphul, Kamleshun, Sharma, Shivani
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: Activated protein C (APC) plays a crucial role in breaking down factor Va and VIIIa, preventing excessive blood clotting. APC resistance occurs when protein C is unable to degrade these factors, leading to a higher risk of thrombosis. This condition can be either hereditary or acquired, with the most common cause being the factor V Leiden mutation. While previous studies have indicated that APC resistance increases the likelihood of acute ischemic stroke (AIS), their specific outcomes have not been extensively studied. Our research aims to bridge this gap via a national study. Methods: We used hospital records via the National Inpatient Sample (NIS) for our study. It consists of de-identified in-patient data, released on an annual basis by HCUP, AHRQ, and collaborating hospitals. Patients admitted with a primary diagnosis of AIS were recruited. We excluded all hospitalizations of ages
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2023-186928