Double Hit Lymphomas: Evaluation of Prognostic Factors and Impact of Therapy

• Published in: Blood 2012-11, Vol.120 (21), p.1619-1619
• Main Authors: Abramson, Jeremy S., Barnes, Jeffrey A., Feng, Yang, Takvorian, Tak, Neuberg, Donna S., Hochberg, Ephraim P., Sohani, Aliyah R.
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V120.21.1619.1619

Abstract 1619 Double-hit lymphomas (DHL) harboring rearrangements or additional copies of MYC and BCL2 or less commonly BCL6 have been associated with a poor prognosis, but data remains limited. We conducted a retrospective analysis of DHLs to evaluate for factors associated with an improved prognosis. We identified DHL cases diagnosed 2004–2011. Cases were included if they had rearrangements or extra copies of MYC as well as BCL2 or BCL6, or both. Overall survival (OS) was defined as the time from biopsy to death. Progression-free survival (PFS) was defined as time from biopsy to progression or death without progression. OS and PFS curves were obtained using the Kaplan-Meier method with 90% confidence intervals calculated using Greenwood’s formula. Univariate analysis for risk factors was conducted with the log-rank test using a two-sided significance level of 0.05. Stepwise multivariable Cox regression analyses of PFS and OS were utilized to identify significant prognostic factors. Thirty-four DHL patients were included in the analysis. Twenty-eight patients (82%) had rearrangements of both MYC and BCL2, one of whom also had a BCL6 translocation. Two patients had rearrangements of MYC and BCL6. One patient each had rearrangement of MYC with 8 copies of BCL2, rearrangement of BCL2 with 3 copies of MYC, rearrangement of BCL2 with 4 copies of MYC, and rearrangement of BCL6 with 4 copies of MYC. Based on the WHO classification, 35% had DLBCL morphology, while 65% had B-cell lymphoma unclassifiable with intermediate features between DLBCL and BL (BCLU). Median Ki67 was 90% (range 25–100%). The median age was 63 (range 32–86 years), and gender was evenly divided. Prior follicular lymphoma was present in 10 patients (29%). Twenty-nine patients (85%) had advanced stage disease, with 27 (79%) presenting at stage IV and 2 at stage III. Five patients (15%) had limited-stage disease. Extranodal disease was present in 26 (77%), including 6 patients with CNS disease, 9 with leukemic disease, and 15 with marrow disease. Eighteen patients (53%) had 2 or more extranodal sites involved at diagnosis. Performance status was 0–1 in the majority of patients (88%). LDH was elevated in 30 patients (88%). The mean LDH was 1388 (range 151 – 10840). The IPI score was 0–1 in 15%, 2–3 in 35% and 4–5 in 50%. Fifteen (44%) patients were treated with R-CHOP, 6 (18%) with R-CODOX-M/IVAC, 12 (35%) with R-EPOCH, and 1 patient with best supportive care. Two patients underwent consolidative