Partial Splenic Embolization For The Treatment Of Steroid-Resistant Chronic Idiopathic Thrombocytopenic Purpura

• Published in: Blood 2013-11, Vol.122 (21), p.3543-3543
• Main Authors: Nakaseko, Chiaki, Togasaki, Emi, Shimizu, Naomi, Sakaida, Emiko, Takeuchi, Masahiro, Ohwada, Chikako, Takeda, Yusuke, Sakai, Shio, Tsukamoto, Shokichi, Kawaguchi, Takeharu, Muto, Tomoya, Iseki, Tohru, Yokote, Koutaro
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V122.21.3543.3543

Although thrombopoietin-receptor agonists have recently been introduced for the treatment of refractory immune thrombocytopenia (ITP), splenectomy is still the standard treatment option for patients with steroid-refractory ITP. However, open and laparoscopic splenectomy is associated with a mortality rate of 1.0% and 0.2%, respectively, and the major known long-term risk of splenectomy is severe bacterial sepsis. Partial splenic embolization (PSE) is an alternative to splenectomy for patients with steroid-refractory (Kimura et al., AJR 2002). PSE does not require general anesthesia and has not been associated with severe complications. In this study, we analyzed the efficacy and long-term outcomes of PSE in steroid-refractory ITP patients. Between 1988 and 2009, 77 patients with chronic ITP [30 men and 47 women, 16.5–80.9 years old (median age, 46.5 years)] underwent PSE at Chiba University Hospital. Almost all patients did not respond to steroid treatment or other therapies including Helicobacter pylori eradication and immunosuppressive drugs. A 5-French catheter was introduced via the femoral artery to the middle splenic artery and a 0.089-cm guidewire was inserted coaxially. Embolization of intrasplenic arterial branches was performed by the injection of 2 x 2 mm fragments of Gelfoam and an antibiotic solution. Splenic embolization was monitored angiographically during the procedure, and embolization was stopped after 70% of the splenic parenchyma had been ablated. The therapeutic response to PSE was evaluated on the basis of the platelet (PLT) count at 1 year after PSE: a complete response (CR) was defined as PLT count of more than 10 x 1010/L without any medication and a partial response (PR) was defined as PLT count = 5–10 x 1010/L without any medication. Patients who required medication to maintain a PLT count of more than 5 x 1010/L or patients with a PLT count of less than 5 x1010/L were considered to have no response (NR). The average PLT count prior to PSE was 2.7 ± 2.4 x 1010/L. The mean time to achieve the peak PLT count was 10.2 ± 5.2 days after PSE. The PLT count was 11.1 ±10.3 x 1010/L (n = 74), 9.8 ± 8.3 x 1010/L (n = 70), 9.1 ± 8.2 x 1010/L (n = 65), and 9.1 ± 7.5 x 1010/L (n = 69) at 1 month, 3 months, 6 months, and 1 year, respectively. One year post PSE, CR or PR was obtained in 33 (58%) of the evaluable 57 patients and 24 patients (42%) had NR. The group in which the peak PLT count after PSE was over 30.0 x 1010/L showed a significant