Gut microbiota Parabacteroides distasonis enchances the efficacy of immunotherapy for bladder cancer by activating anti-tumor immune responses

Objective Bladder cancer(BCa) was a disease that seriously affects patients’ quality of life and prognosis. To address this issue, many researches suggested that the gut microbiota modulated tumor response to treatment; however, this had not been well-characterized in bladder cancer. In this study,...

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Bibliographic Details
Published in:BMC microbiology 2024-07, Vol.24 (1), p.237-15, Article 237
Main Authors: Wang, Benlin, Qiu, Yifeng, Xie, Ming, Huang, Pengcheng, Yu, Yao, Sun, Qi, Shangguan, Wentai, Li, Weijia, Zhu, Zhangrui, Xue, Jingwen, Feng, Zhengyuan, Zhu, Yuexuan, Yang, Qishen, Wu, Peng
Format: Article
Language:English
Subjects:
Aged
Analysis
Animals
Antibiotics
Anticancer properties
Antitumor activity
Bacteria
Bacteroidetes - genetics
Bacteroidetes - immunology
Biological Microscopy
Biomedical and Life Sciences
Bladder
Bladder cancer
Cancer
Cancer therapies
Care and treatment
CD4 antigen
CD8 antigen
Cell death
Composition
Diagnosis
Drug resistance
Effectiveness
Fecal Microbiota Transplantation
Fecal microflora
Feces
Feces - microbiology
Female
Gastrointestinal Microbiome
Growth curves
Gut microbiota
Health aspects
Humans
Immune checkpoint inhibitors
Immune response
Immune system
Immunohistochemistry
Immunotherapy
Immunotherapy - methods
Intestinal microflora
Life Sciences
Lymphocytes
Lymphocytes T
Male
Melanoma
Mice
Mice, Inbred C57BL
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Middle Aged
Monoclonal antibodies
Mycology
Parabacteroides
Parabacteroides distasonis
Parasitology
Pathology
Patients
PD-1 protein
Probiotics
Prognosis
Quality of life
RNA, Ribosomal, 16S - genetics
rRNA 16S
The Impact of gut microbiota on human health
Transcriptomes
Transcriptomics
Transplants & implants
Tumors
Urinary Bladder Neoplasms - immunology
Urinary Bladder Neoplasms - microbiology
Urinary Bladder Neoplasms - therapy
Virology
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