Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) by Rosiglitazone Suppresses Components of the Insulin-Like Growth Factor Regulatory System in Vitro and in Vivo

Rosiglitazone (Rosi) belongs to the class of thiazolidinediones (TZDs) that are ligands for peroxisome proliferator-activated receptor γ (PPARγ). Stimulation of PPARγ suppresses bone formation and enhances marrow adipogenesis. We hypothesized that activation of PPARγ down-regulates components of the...

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Bibliographic Details
Published in:	Endocrinology (Philadelphia) 2007-02, Vol.148 (2), p.903-911
Main Authors:	Lecka-Czernik, B., Ackert-Bicknell, C., Adamo, M. L., Marmolejos, V., Churchill, G. A., Shockley, K. R., Reid, I. R., Grey, A., Rosen, C. J.
Format:	Article
Language:	English
Subjects:	Adipogenesis Adipose Tissue - metabolism Animals Biological and medical sciences Bone growth Bone Marrow Cells - metabolism C cells Cell Line Down-Regulation Drug Administration Schedule Female Fundamental and applied biological sciences. Psychology Growth factors Humans Insulin-Like Growth Factor Binding Protein 2 - blood Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor Binding Protein 4 - antagonists & inhibitors Insulin-Like Growth Factor Binding Protein 4 - genetics Insulin-like growth factor I Insulin-Like Growth Factor I - antagonists & inhibitors Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - secretion Insulin-like growth factor II Insulin-Like Growth Factor II - antagonists & inhibitors Insulin-Like Growth Factor II - metabolism Insulin-like growth factor II receptors Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factors Liver Liver - cytology Liver - metabolism Mice Mice, Inbred C57BL Microarray Analysis Osteoblasts - physiology Osteogenesis Ovariectomy Paracrine signalling Peroxisome proliferator-activated receptors Placebos Post-menopause PPAR gamma - drug effects PPAR gamma - genetics PPAR gamma - metabolism Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - genetics Receptors RNA, Messenger - metabolism Rosiglitazone Somatomedins - metabolism Stromal cells Stromal Cells - drug effects Stromal Cells - metabolism Thiazolidinediones Thiazolidinediones - administration & dosage Thiazolidinediones - pharmacology Transfection Vertebrates: endocrinology
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