Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma

Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting endocrine tumor. Although plasma CT level is a specific and sensitive marker of MTC, its preoperative usefulness in predicting tumor size and postoperative CT normalization has not been documented. From a nationwide database set up by...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2000-02, Vol.85 (2), p.919-919
Main Authors: Cohen, Régis, Campos, José-Marie, Salaün, Carole, Massoud Heshmati, Hassan, Kraimps, Jean-Louis, Proye, Charles, Sarfati, Émile, Henry, Jean-François, Niccoli-Sire, Patricia, Modigliani, Elisabeth
Format: Article
Language:English
Subjects:
Biological and medical sciences
Endocrinopathies
Malignant tumors
Medical sciences
Thyroid. Thyroid axis (diseases)
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c2656-7a1d290f4fd47f1dffc8f123b4ac2bcd86a46df72036d48ba501b8e5870109ab3
cites
container_end_page 919
container_issue 2
container_start_page 919
container_title The journal of clinical endocrinology and metabolism
container_volume 85
creator Cohen, Régis
Campos, José-Marie
Salaün, Carole
Massoud Heshmati, Hassan
Kraimps, Jean-Louis
Proye, Charles
Sarfati, Émile
Henry, Jean-François
Niccoli-Sire, Patricia
Modigliani, Elisabeth
description Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting endocrine tumor. Although plasma CT level is a specific and sensitive marker of MTC, its preoperative usefulness in predicting tumor size and postoperative CT normalization has not been documented. From a nationwide database set up by the French CT Tumor Study Group, 226 MTC patients were selected according to the following criteria: preoperative CT level determination by an immunoradiometric assay (normal value,
doi_str_mv 10.1210/jcem.85.2.6556
format article
fullrecord <record><control><sourceid>pascalfrancis_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1210_jcem_85_2_6556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1279359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2656-7a1d290f4fd47f1dffc8f123b4ac2bcd86a46df72036d48ba501b8e5870109ab3</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhYMoWKtb11m4nTHJJJOZZSm-oGrBCu5CJg9MmUlK0hbs3v9tagU3urpw73cO9xwALjEqMcHoeqnMUDasJGXNWH0ERrilrOC45cdghBDBRcvJ2yk4S2mJEKaUVSPwOY8mrEyUa7c1cCp75dbBOw9nZmv6BCfRwIxop76BYOFiM4QIX9zOQOk1nIe0_tPgKcRB9m6XD8HDvHg0etP3Mn7AxftHDE5nOirnwyDPwYmVfTIXP3MMXm9vFtP7YvZ89zCdzApFalYXXGJNWmSp1ZRbrK1VjcWk6qhUpFO6qSWtteUEVbWmTScZwl1jWMMRRq3sqjEoD74qhpSisWIV3ZBfEhiJfYliX6JomCBiX2IWXB0EK5mU7G2UXrn0qyK8rVibMXbAjNdBRefNKpqUxDJsos-B_rP_AsL4iEs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma</title><source>Oxford Journals Online</source><creator>Cohen, Régis ; Campos, José-Marie ; Salaün, Carole ; Massoud Heshmati, Hassan ; Kraimps, Jean-Louis ; Proye, Charles ; Sarfati, Émile ; Henry, Jean-François ; Niccoli-Sire, Patricia ; Modigliani, Elisabeth</creator><creatorcontrib>Cohen, Régis ; Campos, José-Marie ; Salaün, Carole ; Massoud Heshmati, Hassan ; Kraimps, Jean-Louis ; Proye, Charles ; Sarfati, Émile ; Henry, Jean-François ; Niccoli-Sire, Patricia ; Modigliani, Elisabeth</creatorcontrib><description>Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting endocrine tumor. Although plasma CT level is a specific and sensitive marker of MTC, its preoperative usefulness in predicting tumor size and postoperative CT normalization has not been documented. From a nationwide database set up by the French CT Tumor Study Group, 226 MTC patients were selected according to the following criteria: preoperative CT level determination by an immunoradiometric assay (normal value, &lt;10 pg/mL) within the 6 months prior to surgery, total thyroidectomy and diagnosis of MTC ascertained by histological report including tumor size. Patients were 129 females and 97 males (female/male ratio, 1.3). One hundred and twelve patients (49.6%) had the sporadic variety of the disease, 74 (32.7%) had multiple endocrine neoplasia 2A, three (1.3%) had multiple endocrine neoplasia 2B, and 37 (16.4%) had familial MTC. Median age at diagnosis was 44.8 yr (range, 4.9–80.1 yr). Complete neck dissection was performed in 159 patients (70.4%). Postoperative CT normalization was ascertained by negative response of CT to pentagastrin stimulation (&lt;10 pg/mL in 94 patients. Seventy-one patients were considered as not cured because of residual tumor tissue and/or elevated CT levels. Median tumor size was 11.0 mm (range, 0.2–80.0 mm), significantly larger in females (15.0 vs. 8.0 mm, P &lt; 0.05), and in sporadic forms (15.0 vs. 7.0 mm, P &lt; 0.05). Tumor size was significantly correlated (r2 = 0.52 m, P &lt; 0.01) with preoperative CT levels, the relationship being more straight in familial (r2 = 0.71) than in sporadic (r2 = 0.36) forms. Furthermore, preoperative CT levels under 50 pg/mL appeared to be predictive of postoperative CT normalization (44 of 45 patients). However higher CT levels did not mean absence of postoperative CT normalization (50 of 120 patients). We conclude that low preoperative CT levels are predictive of tumor size and postoperative CT normalization.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jcem.85.2.6556</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Biological and medical sciences ; Endocrinopathies ; Malignant tumors ; Medical sciences ; Thyroid. Thyroid axis (diseases)</subject><ispartof>The journal of clinical endocrinology and metabolism, 2000-02, Vol.85 (2), p.919-919</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2656-7a1d290f4fd47f1dffc8f123b4ac2bcd86a46df72036d48ba501b8e5870109ab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1279359$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Régis</creatorcontrib><creatorcontrib>Campos, José-Marie</creatorcontrib><creatorcontrib>Salaün, Carole</creatorcontrib><creatorcontrib>Massoud Heshmati, Hassan</creatorcontrib><creatorcontrib>Kraimps, Jean-Louis</creatorcontrib><creatorcontrib>Proye, Charles</creatorcontrib><creatorcontrib>Sarfati, Émile</creatorcontrib><creatorcontrib>Henry, Jean-François</creatorcontrib><creatorcontrib>Niccoli-Sire, Patricia</creatorcontrib><creatorcontrib>Modigliani, Elisabeth</creatorcontrib><title>Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma</title><title>The journal of clinical endocrinology and metabolism</title><description>Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting endocrine tumor. Although plasma CT level is a specific and sensitive marker of MTC, its preoperative usefulness in predicting tumor size and postoperative CT normalization has not been documented. From a nationwide database set up by the French CT Tumor Study Group, 226 MTC patients were selected according to the following criteria: preoperative CT level determination by an immunoradiometric assay (normal value, &lt;10 pg/mL) within the 6 months prior to surgery, total thyroidectomy and diagnosis of MTC ascertained by histological report including tumor size. Patients were 129 females and 97 males (female/male ratio, 1.3). One hundred and twelve patients (49.6%) had the sporadic variety of the disease, 74 (32.7%) had multiple endocrine neoplasia 2A, three (1.3%) had multiple endocrine neoplasia 2B, and 37 (16.4%) had familial MTC. Median age at diagnosis was 44.8 yr (range, 4.9–80.1 yr). Complete neck dissection was performed in 159 patients (70.4%). Postoperative CT normalization was ascertained by negative response of CT to pentagastrin stimulation (&lt;10 pg/mL in 94 patients. Seventy-one patients were considered as not cured because of residual tumor tissue and/or elevated CT levels. Median tumor size was 11.0 mm (range, 0.2–80.0 mm), significantly larger in females (15.0 vs. 8.0 mm, P &lt; 0.05), and in sporadic forms (15.0 vs. 7.0 mm, P &lt; 0.05). Tumor size was significantly correlated (r2 = 0.52 m, P &lt; 0.01) with preoperative CT levels, the relationship being more straight in familial (r2 = 0.71) than in sporadic (r2 = 0.36) forms. Furthermore, preoperative CT levels under 50 pg/mL appeared to be predictive of postoperative CT normalization (44 of 45 patients). However higher CT levels did not mean absence of postoperative CT normalization (50 of 120 patients). We conclude that low preoperative CT levels are predictive of tumor size and postoperative CT normalization.</description><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEUhYMoWKtb11m4nTHJJJOZZSm-oGrBCu5CJg9MmUlK0hbs3v9tagU3urpw73cO9xwALjEqMcHoeqnMUDasJGXNWH0ERrilrOC45cdghBDBRcvJ2yk4S2mJEKaUVSPwOY8mrEyUa7c1cCp75dbBOw9nZmv6BCfRwIxop76BYOFiM4QIX9zOQOk1nIe0_tPgKcRB9m6XD8HDvHg0etP3Mn7AxftHDE5nOirnwyDPwYmVfTIXP3MMXm9vFtP7YvZ89zCdzApFalYXXGJNWmSp1ZRbrK1VjcWk6qhUpFO6qSWtteUEVbWmTScZwl1jWMMRRq3sqjEoD74qhpSisWIV3ZBfEhiJfYliX6JomCBiX2IWXB0EK5mU7G2UXrn0qyK8rVibMXbAjNdBRefNKpqUxDJsos-B_rP_AsL4iEs</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Cohen, Régis</creator><creator>Campos, José-Marie</creator><creator>Salaün, Carole</creator><creator>Massoud Heshmati, Hassan</creator><creator>Kraimps, Jean-Louis</creator><creator>Proye, Charles</creator><creator>Sarfati, Émile</creator><creator>Henry, Jean-François</creator><creator>Niccoli-Sire, Patricia</creator><creator>Modigliani, Elisabeth</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200002</creationdate><title>Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma</title><author>Cohen, Régis ; Campos, José-Marie ; Salaün, Carole ; Massoud Heshmati, Hassan ; Kraimps, Jean-Louis ; Proye, Charles ; Sarfati, Émile ; Henry, Jean-François ; Niccoli-Sire, Patricia ; Modigliani, Elisabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2656-7a1d290f4fd47f1dffc8f123b4ac2bcd86a46df72036d48ba501b8e5870109ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Régis</creatorcontrib><creatorcontrib>Campos, José-Marie</creatorcontrib><creatorcontrib>Salaün, Carole</creatorcontrib><creatorcontrib>Massoud Heshmati, Hassan</creatorcontrib><creatorcontrib>Kraimps, Jean-Louis</creatorcontrib><creatorcontrib>Proye, Charles</creatorcontrib><creatorcontrib>Sarfati, Émile</creatorcontrib><creatorcontrib>Henry, Jean-François</creatorcontrib><creatorcontrib>Niccoli-Sire, Patricia</creatorcontrib><creatorcontrib>Modigliani, Elisabeth</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Régis</au><au>Campos, José-Marie</au><au>Salaün, Carole</au><au>Massoud Heshmati, Hassan</au><au>Kraimps, Jean-Louis</au><au>Proye, Charles</au><au>Sarfati, Émile</au><au>Henry, Jean-François</au><au>Niccoli-Sire, Patricia</au><au>Modigliani, Elisabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><date>2000-02</date><risdate>2000</risdate><volume>85</volume><issue>2</issue><spage>919</spage><epage>919</epage><pages>919-919</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting endocrine tumor. Although plasma CT level is a specific and sensitive marker of MTC, its preoperative usefulness in predicting tumor size and postoperative CT normalization has not been documented. From a nationwide database set up by the French CT Tumor Study Group, 226 MTC patients were selected according to the following criteria: preoperative CT level determination by an immunoradiometric assay (normal value, &lt;10 pg/mL) within the 6 months prior to surgery, total thyroidectomy and diagnosis of MTC ascertained by histological report including tumor size. Patients were 129 females and 97 males (female/male ratio, 1.3). One hundred and twelve patients (49.6%) had the sporadic variety of the disease, 74 (32.7%) had multiple endocrine neoplasia 2A, three (1.3%) had multiple endocrine neoplasia 2B, and 37 (16.4%) had familial MTC. Median age at diagnosis was 44.8 yr (range, 4.9–80.1 yr). Complete neck dissection was performed in 159 patients (70.4%). Postoperative CT normalization was ascertained by negative response of CT to pentagastrin stimulation (&lt;10 pg/mL in 94 patients. Seventy-one patients were considered as not cured because of residual tumor tissue and/or elevated CT levels. Median tumor size was 11.0 mm (range, 0.2–80.0 mm), significantly larger in females (15.0 vs. 8.0 mm, P &lt; 0.05), and in sporadic forms (15.0 vs. 7.0 mm, P &lt; 0.05). Tumor size was significantly correlated (r2 = 0.52 m, P &lt; 0.01) with preoperative CT levels, the relationship being more straight in familial (r2 = 0.71) than in sporadic (r2 = 0.36) forms. Furthermore, preoperative CT levels under 50 pg/mL appeared to be predictive of postoperative CT normalization (44 of 45 patients). However higher CT levels did not mean absence of postoperative CT normalization (50 of 120 patients). We conclude that low preoperative CT levels are predictive of tumor size and postoperative CT normalization.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><doi>10.1210/jcem.85.2.6556</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0021-972X
ispartof The journal of clinical endocrinology and metabolism, 2000-02, Vol.85 (2), p.919-919
issn 0021-972X
1945-7197
language eng
recordid cdi_crossref_primary_10_1210_jcem_85_2_6556
source Oxford Journals Online
subjects Biological and medical sciences
Endocrinopathies
Malignant tumors
Medical sciences
Thyroid. Thyroid axis (diseases)
title Preoperative Calcitonin Levels Are Predictive of Tumor Size and Postoperative Calcitonin Normalization in Medullary Thyroid Carcinoma
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A15%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pascalfrancis_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preoperative%20Calcitonin%20Levels%20Are%20Predictive%20of%20Tumor%20Size%20and%20Postoperative%20Calcitonin%20Normalization%20in%20Medullary%20Thyroid%20Carcinoma&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Cohen,%20Re%CC%81gis&rft.date=2000-02&rft.volume=85&rft.issue=2&rft.spage=919&rft.epage=919&rft.pages=919-919&rft.issn=0021-972X&rft.eissn=1945-7197&rft.coden=JCEMAZ&rft_id=info:doi/10.1210/jcem.85.2.6556&rft_dat=%3Cpascalfrancis_cross%3E1279359%3C/pascalfrancis_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2656-7a1d290f4fd47f1dffc8f123b4ac2bcd86a46df72036d48ba501b8e5870109ab3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true