Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its O 7-Propargyl Analogue

Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.

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Published in:Bulletin of the Chemical Society of Japan 2014-04, Vol.87 (4), p.544-549
Main Authors: Hayakawa, Ichiro, Shioda, Shuya, Ikedo, Akiyuki, Kigoshi, Hideo
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Language:English
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description Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.
doi_str_mv 10.1246/bcsj.20130342
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title Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its O 7-Propargyl Analogue
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