EFFECT OF N-ACETYL-L-GLUTAMINE ALUMINUM COMPLEX (KW-110), AN ANTIULCER AGENT, ON THE NON-STEROIDAL ANTI-INFLAMMATORY DRUG-INDUCED EXACERBATION OF GASTRIC ULCER IN RATS

• Published in: Japanese journal of pharmacology 1982, Vol.32(2), pp.307-313
• Main Authors: TANAKA, Hiroshi, SHUTO, Katsuichi, MARUMO, Hirofuto
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.32.307

Gastric ulcer induced by the injection of acetic acid (0.025 ml of 20%) into the gastric wall of rats was healed considerably 5 days after the injection of acetic acid. Non-steroidal anti-inflammatory drugs (NSAID) such as aspirin, indomethacin, and phenylbutazone were given consecutively for 5 days, and they exacerbated the ulcer and enlarged the ulcer area. Aspirin caused exacerbation when it was given for the initial 5 days of the ulcer healing process. Phenylbutazone caused exacerbation by the administration for 5 days at the middle stage of the ulcer healing process. In contrast, indomethacin caused exacerbation not only when it was given for the initial 5 days but also when it was given for the middle 5 days. The effect of the antiulcer agent N-acetyl-L-glutamine aluminum complex (KW-110) on the exacerbation was studied. KW-110 at an oral dose of 500 mg/kg inhibited remarkably the exacerbation induced by all of the NSAID used. The development of gastric lesions induced by these NSAID was also prevented by KW-110. Further study was carried out with regard to the influences of KW-110 on the pharmacological properties of NSAID. The results showed no influences of KW-110 on the antiedematous and antipyretic actions of the NSAID.