Validated Stability-Indicating Chromatographic Methods for the Determination of Veralipride in Presence of Its Degradation Products

Two sensitive and selective chromatographic methods were developed and validated for determination of veralipride in presence of its degradation products. Forced degradation studies were performed, using HCl, NaOH and 3% H₂O₂. The first method is based on thin-layer chromatographic separation of the...

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Bibliographic Details
Published in:Chromatographia 2009, Vol.70 (7-8), p.1299-1302
Main Authors: Salem, Maissa Yacoub, Salama, Nahla Nour El Din, Halim, Lobna Mohammed Abd El, Fattah, Laila El-Sayed Abdel
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biological and medical sciences
Chemistry
Chemistry and Materials Science
Chromatography
General pharmacology
Laboratory Medicine
Limited Short Communication
Medical sciences
Pharmacology. Drug treatments
Pharmacy
Proteomics
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Summary:Two sensitive and selective chromatographic methods were developed and validated for determination of veralipride in presence of its degradation products. Forced degradation studies were performed, using HCl, NaOH and 3% H₂O₂. The first method is based on thin-layer chromatographic separation of the intact drug spot from its degradation, followed by densitometric measurements. The second method is based on isocratic liquid chromatographic separation of the studied drug from its degradation on a reversed phase C₁₈ column. The proposed LC method was utilized to investigate the kinetics of alkaline degradation process of the selected drug at different temperatures.
ISSN:0009-5893
1612-1112
DOI:10.1365/s10337-009-1302-x