Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome

The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pVHL has a molten globule configuration with margina...

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Bibliographic Details
Published in:	PloS one 2014-10, Vol.9 (10), p.e109864
Main Authors:	Shmueli, Merav D., Schnaider, Lee, Herzog, Gal, Gazit, Ehud, Segal, Daniel
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Amino acids Analysis Animals Animals, Genetically Modified Biology and Life Sciences Biotechnology Cancer Carrier Proteins - chemistry Carrier Proteins - metabolism Computer applications Conserved Sequence Disease Models, Animal Drosophila Drosophila melanogaster Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - metabolism Drug development Evolution, Molecular Evolutionary conservation Eye - pathology Genes Green Fluorescent Proteins - metabolism Homology Humans Hydrophobic and Hydrophilic Interactions Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factors In vivo methods and tests Insects Life sciences Ligases Mammals Models, Molecular Molecular Sequence Data Mutation Neoplasia Oxygen Protein binding Protein Folding Protein Stability Protein Structure, Secondary Proteins PvHL protein Sequence Alignment Sequence Homology, Amino Acid Similarity Structure-function relationships Subcellular Fractions - metabolism Transgenic Tumors Vascular endothelial growth factor VHL protein Von Hippel-Lindau disease von Hippel-Lindau Disease - metabolism von Hippel-Lindau Disease - pathology Von Hippel-Lindau Tumor Suppressor Protein - chemistry
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