Clinical Characteristics of Amiodarone-Induced Thyrotoxicosis and Hypothyroidism in Japan

Since amiodarone was introduced in Japan in 1992, the incidence of the drug-induced thyroid dysfunction has been increasing. We studied the thyroid function of 13 patients with amiodarone-induced thyrotoxicosis (AIT) and 11 patients with amiodarone-associated hypothyroidism (AAH) who had been referr...

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Published in:ENDOCRINE JOURNAL 1999, Vol.46(3), pp.443-451
Main Authors: SATO, KANJI, MIYAKAWA, MEGUMI, ETO, MIYUKI, INABA, TAKAKO, MATSUDA, NAOKI, SHIGA, TSUYOSHI, OHNISHI, SATOSHI, KASANUKI, HIROSHI
Format: Article
Language:English
Subjects:
Adult
Aged
Amiodarone
Amiodarone - adverse effects
Anti-Arrhythmia Agents - adverse effects
Antithyroid Agents - therapeutic use
Color flow Doppler sonography
Female
Humans
Hypothyroidism
Hypothyroidism - chemically induced
Hypothyroidism - drug therapy
Iodide
Japan
Male
Methimazole - therapeutic use
Middle Aged
Prednisolone - therapeutic use
Thyrotoxicosis
Thyrotoxicosis - blood
Thyrotoxicosis - chemically induced
Thyrotoxicosis - drug therapy
Thyrotropin - blood
Thyroxine - blood
Time Factors
Triiodothyronine - blood
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Summary:Since amiodarone was introduced in Japan in 1992, the incidence of the drug-induced thyroid dysfunction has been increasing. We studied the thyroid function of 13 patients with amiodarone-induced thyrotoxicosis (AIT) and 11 patients with amiodarone-associated hypothyroidism (AAH) who had been referred to our Institute in the last 6years. AIT and AAH developed after 39±21 and 20±16 months of amiodarone treatment, respectively. One patient developed AAH followed by AIT. The AIT ranged from subclinical to overt thyrotoxicosis. Four patients with moderate to marked AIT were treated with methimazole. Their thyrotoxicosis persisted for 3 to 9months, despite administration of antithyroid agents. One patient with mild thyrotoxicosis was treated with prednisolone, resulting in a euthyroid state in a few months. Eight patients with asymptomatic to moderate thyrotoxicosis resolved spontaneously without any treatment. In four asymptomatic patients with AIT, serum levels of T3 and T4 were in the upper normal range or slightly high (
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.46.443