Alternative Hfq-sRNA interaction modes dictate alternative mRNA recognition

Many bacteria use small RNAs (sRNAs) and the RNA chaperone Hfq to regulate mRNA stability and translation. Hfq, a ring‐shaped homohexamer, has multiple faces that can bind both sRNAs and their mRNA targets. We find that Hfq has at least two distinct ways in which it interacts with sRNAs; these diffe...

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Bibliographic Details
Published in:The EMBO journal 2015-10, Vol.34 (20), p.2557-2573
Main Authors: Schu, Daniel J, Zhang, Aixia, Gottesman, Susan, Storz, Gisela
Format: Article
Language:English
Subjects:
Bacteria
Base Pairing
beta-Galactosidase
Blotting, Northern
ChiX
DNA Primers - genetics
EMBO23
EMBO36
Escherichia coli K12 - genetics
Escherichia coli K12 - metabolism
Escherichia coli Proteins - metabolism
Hfq
Host Factor 1 Protein - metabolism
MgrR
Models, Molecular
Molecular biology
Plasmids - genetics
Protein Binding
Ribonucleic acid
RNA
RNA, Messenger - metabolism
RNA, Small Untranslated - metabolism
RyhB
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