Netrin‐1/DCC‐mediated PLCγ1 activation is required for axon guidance and brain structure development

Coordinated expression of guidance molecules and their signal transduction are critical for correct brain wiring. Previous studies have shown that phospholipase C gamma1 (PLCγ1), a signal transducer of receptor tyrosine kinases, plays a specific role in the regulation of neuronal cell morphology and...

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Bibliographic Details
Published in:	EMBO reports 2018-11, Vol.19 (11), p.n/a
Main Authors:	Kang, Du‐Seock, Yang, Yong Ryoul, Lee, Cheol, Park, BumWoo, Park, Kwang IL, Seo, Jeong Kon, Seo, Young Kyo, Cho, HyungJoon, Cocco, Lucio, Suh, Pann‐Ghill
Format:	Article
Language:	English
Subjects:	Actin Animals Axon guidance Axonogenesis Axons - pathology Axons - physiology Brain Brain - diagnostic imaging Brain - embryology Brain - pathology Cell morphology Colorectal cancer Colorectal carcinoma Corpus callosum Cytology Cytoskeleton DCC DCC protein DCC Receptor - metabolism EMBO05 EMBO27 Embryogenesis Embryonic growth stage Female Kinases Lipase Male Mesencephalon Mesencephalon - embryology Mice Mice, Inbred C57BL Mice, Transgenic Molecular structure Morphology Nervous system Netrin-1 - genetics Netrin-1 - metabolism neural development Olfactory bulb Phospholipase Phospholipase C Phospholipase C gamma - genetics Phospholipase C gamma - metabolism Phosphorylation PLCγ1 Pregnancy Scientific Report Scientific Reports Signal transduction Signaling src-Family Kinases - metabolism Substantia alba Substantia innominata Systems development Tyrosine Wiring
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