Unsuspected hyperosmolality of oral solutions contributing to necrotizing enterocolitis in very-low-birth-weight infants

In recent years necrotizing enterocolitis (NEC) has become a major problem in neonatal intensive care units. Recent incidences as high as 8% in all infants with a birth weight less than 2.5 kg and 14% in those with a birth weight less than 1.5 kg have been reported from one center.1Despite intensive...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1977-10, Vol.60 (4), p.535-538
Main Authors: Willis, D M, Chabot, J, Radde, I C, Chance, G W
Format: Article
Language:English
Subjects:
Administration, Oral
Enterocolitis, Pseudomembranous - etiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Newborn, Diseases - etiology
Lactates - administration & dosage
Osmolar Concentration
Pharmaceutical Vehicles - adverse effects
Sucrose - administration & dosage
Sucrose - adverse effects
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Summary:In recent years necrotizing enterocolitis (NEC) has become a major problem in neonatal intensive care units. Recent incidences as high as 8% in all infants with a birth weight less than 2.5 kg and 14% in those with a birth weight less than 1.5 kg have been reported from one center.1Despite intensive searches for possible causative factors, no definite entity has been identified, but asphyxia,2 circulatory changes associated with exchange transfusion,3 umbilical vessel catheterization,4 immature immune status,5infection,6-8 and hypertonic feedings9 have all been implicated. In the course of a series of nutritional studies involving thriving very-low-birth-weight infants we
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.60.4.535