Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk

Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment. We performed single-cell RNA...

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Bibliographic Details
Published in:	Journal of the American Society of Nephrology 2020-12, Vol.31 (12), p.2793-2814
Main Authors:	Rudman-Melnick, Valeria, Adam, Mike, Potter, Andrew, Chokshi, Saagar M., Ma, Qing, Drake, Keri A., Schuh, Meredith P., Kofron, J. Matthew, Devarajan, Prasad, Potter, S. Steven
Format:	Article
Language:	English
Subjects:	Acute Kidney Injury - etiology Acute Kidney Injury - pathology Animals Basic Research Cell Communication Disease Models, Animal Epithelial Cells - physiology Kidney Tubules, Proximal - pathology Male Mice Phenotype Real-Time Polymerase Chain Reaction Reperfusion Injury - etiology Reperfusion Injury - pathology Sequence Analysis, RNA Stromal Cells - physiology
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